ID G2NEI2_STREK Unreviewed; 389 AA.
AC G2NEI2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|ARBA:ARBA00013346};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE AltName: Full=Protein L-isoaspartyl methyltransferase {ECO:0000256|ARBA:ARBA00030757};
DE AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN ORFNames=SACTE_2605 {ECO:0000313|EMBL:AEN10491.1};
OS Streptomyces sp. (strain SirexAA-E / ActE).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=862751 {ECO:0000313|EMBL:AEN10491.1, ECO:0000313|Proteomes:UP000001397};
RN [1] {ECO:0000313|EMBL:AEN10491.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Adams A., Raffa K.,
RA Adams S., Book A., Currie C., Woyke T.;
RT "Complete sequence of Streptomyces sp. SirexAA-E.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEN10491.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RX PubMed=24710170; DOI=10.1371/journal.pone.0094166;
RA Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F.,
RA Book A.J., Currie C.R., Fox B.G.;
RT "Biochemical properties and atomic resolution structure of a
RT proteolytically processed beta-mannanase from cellulolytic Streptomyces sp.
RT SirexAA-E.";
RL PLoS ONE 9:e94166-E94166(2014).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; CP002993; AEN10491.1; -; Genomic_DNA.
DR RefSeq; WP_014046475.1; NC_015953.1.
DR AlphaFoldDB; G2NEI2; -.
DR STRING; 862751.SACTE_2605; -.
DR KEGG; ssx:SACTE_2605; -.
DR PATRIC; fig|862751.12.peg.2714; -.
DR eggNOG; COG2518; Bacteria.
DR HOGENOM; CLU_037629_0_1_11; -.
DR OrthoDB; 5143400at2; -.
DR Proteomes; UP000001397; Chromosome.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:AEN10491.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001397};
KW Transferase {ECO:0000313|EMBL:AEN10491.1}.
SQ SEQUENCE 389 AA; 42617 MW; 6DE45C7BB11E1AD8 CRC64;
MEETNEEVYP TRRQVGFALV SAGVLTSEWL NAYALVPRRA FLPDVIWPYD MESGQAVHVS
RTDDAGRWQR YADADVPIVT QWDDGGHEGP LPGRLPTSSA SMPSVVFRML DVLTVDEDSR
VLEIGTGTGW NAALLAHRTG DGHVVSVEVD AAVADRAREA LHRFGALVEV VHGDGLCGAP
DHAPFDRVVA TCGVREVPFD WVAQTRPLGV IVAPWGTGFT QDDALVRLQV HASGEFAQGR
FVGPVAFMKA RAHRTAPVDH EAYAPHTGFP AVEESGEVAA EIAAGGRFGP LVFALGLRVP
DCAFSPAQER DGAQPLWFYS RDDRSWACVF LREGRPAQVW QHGPRRLWDE VRAAHAWWCA
QGRPEWDRFG LTVGAAGEYA WLDDPGRPL
//
