ID G2T410_ROSHA Unreviewed; 456 AA.
AC G2T410;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Arylsulfatase regulator (Fe-S oxidoreductase) {ECO:0000313|EMBL:AEN97455.1};
GN OrderedLocusNames=RHOM_11735 {ECO:0000313|EMBL:AEN97455.1};
OS Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=585394 {ECO:0000313|EMBL:AEN97455.1, ECO:0000313|Proteomes:UP000008178};
RN [1] {ECO:0000313|EMBL:AEN97455.1, ECO:0000313|Proteomes:UP000008178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183
RC {ECO:0000313|Proteomes:UP000008178};
RX PubMed=26543119; DOI=10.1128/genomeA.01286-15;
RA Travis A.J., Kelly D., Flint H.J., Aminov R.I.;
RT "Complete genome sequence of the human gut symbiont Roseburia hominis.";
RL Genome Announc. 3:E0128615-E0128615(2015).
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR EMBL; CP003040; AEN97455.1; -; Genomic_DNA.
DR RefSeq; WP_014080466.1; NC_015977.1.
DR AlphaFoldDB; G2T410; -.
DR STRING; 585394.RHOM_11735; -.
DR GeneID; 77459925; -.
DR KEGG; rho:RHOM_11735; -.
DR eggNOG; COG0641; Bacteria.
DR HOGENOM; CLU_009273_3_3_9; -.
DR Proteomes; UP000008178; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21124; SPASM_CteB-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR008792; PQQD.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR024025; SCIFF_rSAM_maturase.
DR InterPro; IPR047602; SPASM_CteB-like.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR NCBIfam; TIGR03974; rSAM_six_Cys; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF05402; PqqD; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008178};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 89..319
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 456 AA; 52534 MW; A20F5EBC52BA070C CRC64;
MVHQYKNNGY DIVLDVNSGA IHVVDDVTYD VIALYEGHTR EEIVNSLRER YPETEVEEAL
DEVQMLVDNE ELFTKDTYEN YIMDFKKRPT VVKALCLHIA HDCNLACQYC FAEEGEYHGR
RALMSFEVGK KALDFLIANS GNRRNLEVDF FGGEPLMNWQ VVKDLVAYGR EQEKLHDKKF
RFTLTTNGVL LNDEVMEFCN REMGNVVLSI DGRKEVHDKM RPFRKGAGSY DLIVPKFQQF
AESRHQDKYY VRGTFTHYNL DFSEDVLHLA DLGFKQISVE PVVAEPKEPY AIREEDLPKL
FEEYDKLAVE MIRRHKSGED FNFFHFMIDL EGGPCVAKRL SGCGSGTEYL AVTPWGDFYP
CHQFVGNEKF LLGNVDEGIL NTDIRDEFKC CNVYAKEKCR KCFARFYCSG GCAANAYNFS
GDICGAYDIG CELQKKRIEC AIMIKAAEEE QKNEEE
//
