ID G2T497_ROSHA Unreviewed; 757 AA.
AC G2T497;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Helicase HerA central domain-containing protein {ECO:0000259|Pfam:PF01935};
GN OrderedLocusNames=RHOM_12970 {ECO:0000313|EMBL:AEN97702.1};
OS Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=585394 {ECO:0000313|EMBL:AEN97702.1, ECO:0000313|Proteomes:UP000008178};
RN [1] {ECO:0000313|EMBL:AEN97702.1, ECO:0000313|Proteomes:UP000008178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183
RC {ECO:0000313|Proteomes:UP000008178};
RX PubMed=26543119; DOI=10.1128/genomeA.01286-15;
RA Travis A.J., Kelly D., Flint H.J., Aminov R.I.;
RT "Complete genome sequence of the human gut symbiont Roseburia hominis.";
RL Genome Announc. 3:E0128615-E0128615(2015).
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DR EMBL; CP003040; AEN97702.1; -; Genomic_DNA.
DR RefSeq; WP_014080708.1; NC_015977.1.
DR AlphaFoldDB; G2T497; -.
DR STRING; 585394.RHOM_12970; -.
DR GeneID; 77460151; -.
DR KEGG; rho:RHOM_12970; -.
DR eggNOG; COG0433; Bacteria.
DR HOGENOM; CLU_367957_0_0_9; -.
DR OrthoDB; 9806951at2; -.
DR BioCyc; RHOM585394:G1H02-2578-MONOMER; -.
DR Proteomes; UP000008178; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR002789; HerA_central.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42957; HELICASE MJ1565-RELATED; 1.
DR PANTHER; PTHR42957:SF1; HELICASE MJ1565-RELATED; 1.
DR Pfam; PF01935; DUF87; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008178};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 429..520
FT /note="Helicase HerA central"
FT /evidence="ECO:0000259|Pfam:PF01935"
SQ SEQUENCE 757 AA; 84489 MW; C4AEA60E96B551C4 CRC64;
MKRQLSQLQR LLVAGIYIFI IVMIDGLLNG GIADILNQSE AASVWFFSGI LLIIMGMYVT
EPYFSSPTDT LSNSISLILV LLAITNRQEL NGYVELLVYA VCMFILSIFH MIVKNYNEKA
KRISFWCLKH LGSSKTMFSV VYLVSAFSFF RDNTPMLFAA IALWICMVPI GLVESIIAQF
SQLMGIIKEK DIDSCIGVAI KNSESNLYTI SVPKTDEKEK LVSSSRNSVY AVKVDSDSYC
LGIETQRKNL IDSIWISIML LDNAELEITL SDLEDIGINI NYTENLGAAH VLNEGKIKQS
ILEQLKSSTI FMERDDFIGF VLPESNVSTI RFNTCKIDEM RLTEGTIVKT HIAGSEVLYQ
VINGITKIAS NSADSEYGYM CAVARKLGHY DAEHHEIKHV NWTPKVYEPV YLCKVNRDID
LQEIAKTSIG RLPGSDMSIP IKNINALVTH NTAVLGILGV GKSCLTFELI KKIVAAGIKV
ICLDITNQYA SDNGLYKYIP EAQIVSDLLQ EKIDELESQS MRTGTSDSKS SWGNVENFKK
LMESAVSGFM DANNKSVMVL NPEKYIVRQA ATDFRITELK DVSLVEKVQI ISEIVLKKCM
DLGQIDRARC CVVYEEAHSL TPEFNSVVVK DDNSHANGTA KVILQGRKYG LGCIIVTQRT
ANVTKSILNQ CNTIFALRVF DDTGKSFLEN YIGRDYSDTL PTLEERHAIA IGKGIGLKQP
VILQLNDMKY LQTNDGEEIV EKNECVDVET EEITPNL
//
