ID G2WS78_VERDV Unreviewed; 332 AA.
AC G2WS78;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=NAD(P)H-dependent D-xylose reductase {ECO:0000313|EMBL:EGY13729.1};
GN ORFNames=VDAG_00411 {ECO:0000313|EMBL:EGY13729.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY13729.1, ECO:0000313|Proteomes:UP000001611};
RN [1] {ECO:0000313|Proteomes:UP000001611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC {ECO:0000313|Proteomes:UP000001611};
RX PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT "Comparative genomics yields insights into niche adaptation of plant
RT vascular wilt pathogens.";
RL PLoS Pathog. 7:E1002137-E1002137(2011).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR EMBL; DS572695; EGY13729.1; -; Genomic_DNA.
DR RefSeq; XP_009650083.1; XM_009651788.1.
DR AlphaFoldDB; G2WS78; -.
DR STRING; 498257.G2WS78; -.
DR EnsemblFungi; EGY13729; EGY13729; VDAG_00411.
DR GeneID; 20701874; -.
DR KEGG; vda:VDAG_00411; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; G2WS78; -.
DR OMA; IRYCDFQ; -.
DR OrthoDB; 5305445at2759; -.
DR Proteomes; UP000001611; Chromosome 2.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF218; NADPH-DEPENDENT ALDOSE REDUCTASE GRE3; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001611}.
FT DOMAIN 21..311
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 53
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 115
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 82
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 332 AA; 36005 MW; 529EBC27DA96C61D CRC64;
MKGPSIAASI PRLKLSSGHV GFGLWKVPAA QTADAVYGAI KAGYRHIDGA YGYANSAEAG
QGVRRAIAHG LVSRDDLFIT SKLWNNHHAP AHATRMANEE LRAWGLDHLD LYLIHFPIAT
QWVDPSVSRF PSWHADAAKT RLHPRARVPL ADTWRALEAL VDAPGVRAGP LRSIGVSNFD
AQLLCDLLAY ARVPPAVLQV EHHPYLAQPQ LVAAARETGV AVTAYSTFGP QSFLELGNPR
AAAMPPLMDV PLVKAIAARH GRTPAQVLLR WCTQRGIVVI PKSMRAERVR ENLDCCGFDL
EAAELEAISG LDRGLRFNDP GVTHGGSVRI FT
//
