ID G2X0H1_VERDV Unreviewed; 792 AA.
AC G2X0H1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=VDAG_03750 {ECO:0000313|EMBL:EGY22312.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY22312.1};
RN [1] {ECO:0000313|EMBL:EGY22312.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY22312.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; DS572700; EGY22312.1; -; Genomic_DNA.
DR RefSeq; XP_009652129.1; XM_009653834.1.
DR AlphaFoldDB; G2X0H1; -.
DR STRING; 498257.G2X0H1; -.
DR EnsemblFungi; EGY22312; EGY22312; VDAG_03750.
DR GeneID; 20705213; -.
DR KEGG; vda:VDAG_03750; -.
DR eggNOG; KOG1123; Eukaryota.
DR HOGENOM; CLU_008213_0_0_1; -.
DR InParanoid; G2X0H1; -.
DR OMA; RCQEIDY; -.
DR OrthoDB; 1360679at2759; -.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:EnsemblFungi.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:EnsemblFungi.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:EnsemblFungi.
DR GO; GO:0097550; C:transcription preinitiation complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:EnsemblFungi.
DR GO; GO:0015616; F:DNA translocase activity; IEA:EnsemblFungi.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:EnsemblFungi.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0000019; P:regulation of mitotic recombination; IEA:EnsemblFungi.
DR GO; GO:0001111; P:RNA polymerase II promoter clearance; IEA:EnsemblFungi.
DR GO; GO:0001113; P:transcription open complex formation at RNA polymerase II promoter; IEA:EnsemblFungi.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EGY22312.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EGY22312.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:EGY22312.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 349..512
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 566..717
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 88263 MW; 6428B94A85EF7129 CRC64;
MPPKRKAIGA VTGGGKVGKG SRVSTPAGAA TPRSIGSDNE SSAAEALSEG EEDVNIEKNV
GHFSVEGYER PSKSATSHIF GKRDYSYLNL KPDFQNRPLW IDASKARIFL ESFSPLAQQC
QDFLITIAEP ISRPSFVHEY ALSPHSLYAA VSVGLSPADI INTLERFLKT PLPKQIREFI
EGCTASFGKV KLVLKNTKYF VESADPVVLQ KLLQDPIIGP LRTHTGSGAI TTTAAPKQAP
LVIPGTTNAA GVRQAGQANN AQGADADKAK EDEVYAALND DDDEEAEFTH SFEIPDSAVE
DVQKRCLDLQ YPVLEEYDFR KDEFNANLEI DLRPGAQIRP YQEKSLSKMF GNGRAKSGII
VLPCGAGKTL VGITAACTVK KGVIVLCTSS MSVVQWRNEF LKWSNIKPED IAAFTSDNKG
QTFTGSTGII VTTYSMVTQT RERSHEAKKM MDFLQHREWG LMLLDEVHVV PANIFRKVTS
SIKTHSKLGL TATLLREDDK ISDLNFLIGP KLYEANWMEL SQQGHIARVQ CAEVWCSMPT
EFYDEYLKAP PRKRSLLYIM NPAKFQACQY LINYHESRGD KIIVFSDNVY ALKAYAMKLK
KVFIYGETGQ AERLQVLENF QHNPQVNTLF LSKIGDTSLD LPEATCLIQI SSHYGSRRQE
AQRLGRILRA KRRNDEGFNA FFYSLVSKDT SEMFFSSKRQ AFLVDQAERR ELLEKVLVEN
VGNEEEFVDD LFHSGTMGRK PKKKGARRTA GMLGDLSGGQ DMAYIEQNKK TKTKKGESSA
FFRKIQRQAA KK
//
