ID   G2X2L5_VERDV            Unreviewed;      1113 AA.
AC   G2X2L5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Lovastatin nonaketide synthase {ECO:0000313|EMBL:EGY23101.1};
GN   ORFNames=VDAG_04539 {ECO:0000313|EMBL:EGY23101.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY23101.1};
RN   [1] {ECO:0000313|EMBL:EGY23101.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY23101.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA   Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA   Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS572701; EGY23101.1; -; Genomic_DNA.
DR   RefSeq; XP_009649281.1; XM_009650986.1.
DR   AlphaFoldDB; G2X2L5; -.
DR   STRING; 498257.G2X2L5; -.
DR   EnsemblFungi; EGY23101; EGY23101; VDAG_04539.
DR   GeneID; 20706002; -.
DR   KEGG; vda:VDAG_04539; -.
DR   eggNOG; KOG1202; Eukaryota.
DR   HOGENOM; CLU_281462_0_0_1; -.
DR   InParanoid; G2X2L5; -.
DR   OMA; TISEYRW; -.
DR   OrthoDB; 5396558at2759; -.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
FT   DOMAIN          1..94
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
SQ   SEQUENCE   1113 AA;  120952 MW;  841EA014DA1592F6 CRC64;
     MQDTRFTALV LPCGHLEGCA GLAGLLRASL AVQHGVIPPN IHFDALNPAV KPFYTNLCVP
     TSPLAWPDTH GQPRRASVNS FGFGGTNAHT IVESYDTPTE TFPSSQQTAA ATLVARQEAD
     KFGLVGPFVF LARSRTSPSQ SLRQTSDHLR INPALDLDSL SSVLHSKRSA LTYRIVIPAT
     TSRQTLLDSL EEHVKLASSA QSSESFGVRA LNEPGATKQP GILGIFTKQV TKVINVDWLL
     HGAQAAQMGR HLVQHCKTFS QSIQKCEVDL KSLPEGPTWS LIEELVAEEK VSRLSQAVIS
     QPLCTALQIA LVDLLKTVGM EFAAVVGHSS GETGAAYAAG LLSRRHAMGI AYYRGQVAHL
     AKGPGGKAGG MIAAALTFQD AKSLCSEARF KGRGQILFPG AGYVSIAVEA SKAFVQGRPI
     KLVEARDMNI PKALVIGEDK GVEVVFTMRS QTLHTSVSDG SSLEAEFVAC SCSYERVLDK
     TCDARLFIHL GPTGSEDLPA NPISQTELTP LDTDRFYRAV SEIDLGYDGA FRALHSISRS
     WGHAKASASW SSDDIAIGCS LHPAVLDVAF QVGLGTFLST AEKSMRSPLL PVGIRRAFIN
     PNQNYEDEPG STNIEIEAMM STANAGVVEV DISLCAKKTN ETQSCGIQID GLILKAIAEP
     QPSEDRNLFV KTIWDVDSAY GLAVTPPTPA NEAASSTVID ACERITLFYM QNLIRELSAQ
     DLKSASWYHQ ELFSYIHTTL STTREKRHAI LREGWLDDDR ETILKLIDEH PESVDIEMLV
     AVELPHGNMH YLDFDRPEAW NADVLVRHVL LMAFTLASST TTQEMLWSEE PEVLVKGDEI
     LVPRIVPDHV ANETLNAKRR KISKLVTTER ITIDSSDPSS QLPQLLTGDS LSVPERYTAV
     DVKFSLALQT GVENPCFLCF GRVQSSGQLA DVGEVLVLSA IDSSTVVAPT ESLLECCDAQ
     AINGESLVGT ASALIALQVV RRVPQHGTTL VFGATVGMAH AISAVAAGTG HSILFVAVDS
     VDEKNREDWI MLHPRAAARV ARRLIPKDTS LVINLSKENL ETIVEFLPCF ASFRPMILEV
     FFTNLARRSL LYWAKRMTRT IHQPKKKPAN YLP
//