ID   G2X4D3_VERDV            Unreviewed;      1046 AA.
AC   G2X4D3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN   ORFNames=VDAG_05015 {ECO:0000313|EMBL:EGY23577.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY23577.1, ECO:0000313|Proteomes:UP000001611};
RN   [1] {ECO:0000313|Proteomes:UP000001611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC   {ECO:0000313|Proteomes:UP000001611};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
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DR   EMBL; DS572703; EGY23577.1; -; Genomic_DNA.
DR   RefSeq; XP_009653046.1; XM_009654751.1.
DR   AlphaFoldDB; G2X4D3; -.
DR   STRING; 498257.G2X4D3; -.
DR   EnsemblFungi; EGY23577; EGY23577; VDAG_05015.
DR   GeneID; 20706478; -.
DR   KEGG; vda:VDAG_05015; -.
DR   eggNOG; KOG2024; Eukaryota.
DR   HOGENOM; CLU_002346_0_0_1; -.
DR   InParanoid; G2X4D3; -.
DR   OMA; EITDFCH; -.
DR   OrthoDB; 276651at2759; -.
DR   Proteomes; UP000001611; Chromosome 4.
DR   GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR004199; B-gal_small/dom_5.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR006101; Glyco_hydro_2.
DR   InterPro; IPR023232; Glyco_hydro_2_AS.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR023230; Glyco_hydro_2_CS.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR032312; LacZ_4.
DR   PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR46323:SF1; LACTASE; 1.
DR   Pfam; PF02929; Bgal_small_N; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   Pfam; PF16353; LacZ_4; 1.
DR   PRINTS; PR00132; GLHYDRLASE2.
DR   SMART; SM01038; Bgal_small_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR   PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001611}.
FT   DOMAIN          754..1042
FT                   /note="Beta galactosidase small chain/"
FT                   /evidence="ECO:0000259|SMART:SM01038"
SQ   SEQUENCE   1046 AA;  117056 MW;  5CD269343D74F6EC CRC64;
     MSPKSIPPQE IEGTPDWQHQ AVFRRNTLPA RSYHIPETSL LLNGQWEFSY TSCPEESPQP
     GDEDVPEDNW GTIEVPGHWQ LQGHGRPHYT NTVFPIPVCP PFAPTDNPTG VYRRTFNVPS
     TWDASAQLRL RFDGVDSAYH IYVNGALVGY AEGSRNASEF DVTDFVKHDA PNDLFVKVYQ
     WSSATYIEDQ DQWWLSGIFR DVHLLAFPKT DRIDDWFLRT DLDAKYENAT LQATVDVTAS
     KSDSLKITLK ELVKNGGAVI TTKDAPVKSG DTKIDLDLAV SNPKKWTAET PYLYQVEITL
     GAHTIQQNIG FRKVELKGGL IRVNGVPIRI YGVNRHEHHP KFGRAVPLDF IKRDLLLMKT
     HNINSLRCSH YPPHPKLFDM CDELGLWVMD EADLETHGFY DCIARPLDIP EEWDYEERKK
     QTFPPAGKYT SQNPDWKEAY VDRMVQLVQR DKNHSSIIMW SLGNEAFYGD NHKAMYEYGK
     AFDPTRPIHY EGDVDAVTAD MFSYMYPPID RLLHLMKTAG VKEDGSWDKP IVLCEYAHAM
     GNGPGALDDY VETFEANERL QGGYIWEWAN HGIWKEDPDG KKYYAYGGDF DDFPNDGTFV
     MDGLLHSTHE PTLGLVQLKK SYQPLLLSVE GGKLVIKNKY DFVGVQHLSA TYKVEELGES
     TSHIAAGSLE IPAVAAGETV SVDLPASLSN IKSTKDVYLT VSFRLKESTN WAEPSHEIAW
     IQHQLSSAEA PASAAALNTL TSKLTVEKTR ARATISGLDF SFVFDTARGL LVSWTAGDKT
     LLEKDPATGA ALIPNFWRPP TDNDVPVACV YWKRFGVHEL TSQLRSIDIV ESADKVEIST
     KTFLSPPVLA WGFETTSKYT ISATGKLTVD VDLTPTGRMP TTIPRAGFNL HLPKALSQVK
     YLGLGPDESY PDKQTSQRVG VYSATVPELQ THYEVPQENG NRMATRYVTL TEGGHGRGFR
     ATPSDASAWT DESWRNFSFR ASHYSADTLH FAKHPCDLVE ADATLLRLDA RVAGVGSAAC
     GPGPREDLLV KTKPLKFGFV LERVGF
//