ID G2X5E0_VERDV Unreviewed; 1273 AA.
AC G2X5E0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:EGY14281.1};
GN ORFNames=VDAG_05445 {ECO:0000313|EMBL:EGY14281.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY14281.1};
RN [1] {ECO:0000313|EMBL:EGY14281.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY14281.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; DS572704; EGY14281.1; -; Genomic_DNA.
DR RefSeq; XP_009650635.1; XM_009652340.1.
DR AlphaFoldDB; G2X5E0; -.
DR STRING; 498257.G2X5E0; -.
DR EnsemblFungi; EGY14281; EGY14281; VDAG_05445.
DR GeneID; 20706908; -.
DR KEGG; vda:VDAG_05445; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_0_1_1; -.
DR InParanoid; G2X5E0; -.
DR OMA; WWFDVES; -.
DR OrthoDB; 2786103at2759; -.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0032934; F:sterol binding; IEA:EnsemblFungi.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:EnsemblFungi.
DR GO; GO:0015918; P:sterol transport; IEA:EnsemblFungi.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1273
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003439461"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1212..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 587..761
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1273 AA; 140261 MW; CF5CC8F6FB9CBDE4 CRC64;
MTQLRNMLGA LLLAPLAMGA SPLTPRHEAG RCAIRGHCGS KSWFGKQLPC VDNGLAEDPD
EELRNQIMEV CGEKWASGPV CCDAEQVTAL SSNLGTPKQI LSSCPACKEN FFNLFCTFTC
SPDQSLFLNV TKTQDKNGKT MVTELDQLIS ETYGTGFYDS CKEVKFGPSN SKAMDFIGGS
AKNYSQMLKF LGDEKAIGSP FQINFPTEYD EPHMGPLDMA PKKCNDEDPN FRCACVDCPE
VCPELPAVRP PGSCHVGALP CLSFASIFSY SVLLFSAIAA VIGHVAWRRH ARRRSERLRL
LQDASPSDDE DEGDLVQNGA MLDRPQRYYK INTWCDAAFS KLGHFAARFP AITIGTSIVL
VAVLSAGLVR FDLERNPARL WVSPTSAAAE EKAFFDANFG PFYRAEKVFL VNDTLPRGSG
TVLSYETLLW WMEIEKSVLS LKGPNYGATL TDVCFKPDGT NCVVQSVSAY FSNEPSLVDK
RHWQEDLRAC AKSPVECRPE YGQPLEPNAI LGDWGSDPVN ATAMTVNWVV KNAEENSPEV
ERAMDWERAL RDRLLEVQKE AEERGLRLSF STEISLEQEL NKSTNTDAKI VVISYLVMFL
YASFALGSTT LSIREMVRNP AIAFVQSKFT LGVVGILIVL MSISASIGLF SWAGLKATLI
IAEVIPFIVL AVGVDNIFLI VHEFERVNVS HPDSMVEERV AKALGRMGPS ILLSALTETV
SFALGAFVGM PAVRNFAAYA AGAVFINAIL QITMFVSVLA LNQMRVEDHR ADCFPCIQVK
AARVHLAGGN GNANARYYEV PEESWLQQFI RRTYAPFILG KKVKTVIIAV FLGFFAAGIA
LIPEVKLGLD QRVALPDDSY LIPFFNDLYN YLDTGPPVYF VTRELNVTER QHQQEICARF
TTCEQTSLAN LLEGERKRPE VSFIATPAAS WVDDFFFWLN PDLGDQCCVE NGKACFADRD
PEWDITLHGM PEGDEFVHYL EKFLTSPTNA DCPLGGQAAY SDAVVIDKKR ETIAASHFRA
MHTPLRSQDD FIHAMSAARR IASEIKKETG VEVFPYSLFY IFFDQYATIV SLAGKLLGSA
VAIIFVIATI LLGSPLTALV VTITVCMTVV DIIGAMAVFD VSLNAVSLVN LIICVGIGVE
FCAHIARAFM FPSRTVMERA KNRFRGRDAR AWTALVNVGA SVFSGITVTK LLGVCVLAFT
RSKIFEIYYF RVWLALVVFA ATHALIFLPV ALSLLGGAGY VDPESEGGLE QDLASRRYRA
LVPDGESDSE DDY
//
