ID   G2X7V2_VERDV            Unreviewed;       375 AA.
AC   G2X7V2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   03-MAY-2023, entry version 44.
DE   RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN   ORFNames=VDAG_06560 {ECO:0000313|EMBL:EGY15070.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY15070.1, ECO:0000313|Proteomes:UP000001611};
RN   [1] {ECO:0000313|Proteomes:UP000001611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC   {ECO:0000313|Proteomes:UP000001611};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the CDC37 family.
CC       {ECO:0000256|ARBA:ARBA00006222}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS572706; EGY15070.1; -; Genomic_DNA.
DR   RefSeq; XP_009657233.1; XM_009658938.1.
DR   AlphaFoldDB; G2X7V2; -.
DR   STRING; 498257.G2X7V2; -.
DR   EnsemblFungi; EGY15070; EGY15070; VDAG_06560.
DR   GeneID; 20708023; -.
DR   KEGG; vda:VDAG_06560; -.
DR   eggNOG; KOG2260; Eukaryota.
DR   HOGENOM; CLU_033261_0_0_1; -.
DR   InParanoid; G2X7V2; -.
DR   OMA; CINLEME; -.
DR   OrthoDB; 1329460at2759; -.
DR   Proteomes; UP000001611; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:EnsemblFungi.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:EnsemblFungi.
DR   Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR   InterPro; IPR004918; Cdc37.
DR   InterPro; IPR013873; Cdc37_C.
DR   InterPro; IPR013874; Cdc37_Hsp90-bd.
DR   InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR   InterPro; IPR013855; Cdc37_N_dom.
DR   PANTHER; PTHR12800; CDC37-RELATED; 1.
DR   PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR   Pfam; PF08564; CDC37_C; 1.
DR   Pfam; PF08565; CDC37_M; 1.
DR   Pfam; PF03234; CDC37_N; 1.
DR   SMART; SM01069; CDC37_C; 1.
DR   SMART; SM01070; CDC37_M; 1.
DR   SMART; SM01071; CDC37_N; 1.
DR   SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001611}.
FT   DOMAIN          2..188
FT                   /note="Cdc37 N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01071"
FT   DOMAIN          96..254
FT                   /note="Cdc37 Hsp90 binding"
FT                   /evidence="ECO:0000259|SMART:SM01070"
FT   DOMAIN          271..368
FT                   /note="Cdc37 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01069"
FT   REGION          97..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  41732 MW;  7C7C4ADDD98EE1DD CRC64;
     MPVDYSKWDA LELSDDSDIE VHPNVDKRSF IRAKQNQIHQ ERQQRKHQIE TLKYERVINE
     GLMRRISALL SALKAHAAVA ETRNPGEVAF QAVLESAGRP EDDQPPPRPA GVHTESEPLP
     SYSKMMATLL DQPSPAAQLF AQIRANDYAA SLSFLSKHPE ILTERETDGL LVMAFDAALE
     RKDDWSRQCV HQALLLQYCR ALGKDGVAMF FKRITTKGHQ AQEVFYKDVT DTYARIRTRA
     REIVAERAKE PAEGVEQIQL HAVEPGTEIK IRIPPADSEE VEVKEACLIF ESFSDEFRKA
     LETGSLDKVN HVLGNMTVEA AEDVVAKLGD AGILSLEERI IDATTEEGRK ALKEMEAAQT
     GTGAGSESGY APDPE
//