ID G2X957_VERDV Unreviewed; 467 AA.
AC G2X957;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012256};
DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
DE AltName: Full=Glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00032953};
DE AltName: Full=Serine methylase {ECO:0000256|ARBA:ARBA00031137};
GN ORFNames=VDAG_06689 {ECO:0000313|EMBL:EGY15525.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY15525.1};
RN [1] {ECO:0000313|EMBL:EGY15525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY15525.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Interconversion of serine and glycine.
CC {ECO:0000256|ARBA:ARBA00002224}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
CC (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001528};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; DS572708; EGY15525.1; -; Genomic_DNA.
DR RefSeq; XP_009657688.1; XM_009659393.1.
DR AlphaFoldDB; G2X957; -.
DR STRING; 498257.G2X957; -.
DR EnsemblFungi; EGY15525; EGY15525; VDAG_06689.
DR GeneID; 20708152; -.
DR KEGG; vda:VDAG_06689; -.
DR eggNOG; KOG2467; Eukaryota.
DR HOGENOM; CLU_022477_0_1_1; -.
DR InParanoid; G2X957; -.
DR OMA; CATTHKV; -.
DR OrthoDB; 5358603at2759; -.
DR UniPathway; UPA00193; -.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 2.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF64; SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00464; SHMT; 2.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 63..257
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT DOMAIN 258..399
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 467 AA; 50824 MW; A924CC5261550B4B CRC64;
MSASALRSTS RALRRCASPA AAAIIKRPTA HARSAPVLLS RGAVRPLSSL NVEGQQQLLS
SNLQQADPAV FDIIEKEKNR QKHFINLIPS ENFTSQAVLD ALGSVMQNKY SEGYPGARYY
GGNEFIDQSE RLCQQRALEA FDLDASQWGV NVQALSGAPA NLYVYSALMN THDRLMGLDL
PHGGHLSHGY QTPTKKISAI SKYFETVPYR LNETTGIIDY DKLEEMAIIY RPKIIVAGAS
AYSSLIDYKR IREICDKNPI NSSVFPGHQG GPHNHTITAL SVALKQAQTP EFRAYQTQVL
SNAKALAHRL GESKEKGGLG YKLVGGGTEN HLVLLDLKPQ GIDGSRVERV LELVGVASNK
NTVPGDRSAL VPGGLRIGTP AMTTRGFSEE DFGRVADIID RAVTIAVRID KAAKKAAAER
GEKKPGLQRI FMAHLGNGDS DPEIVQLRSE VSDWVGTYPL PWVSSRA
//