ID G2X9G3_VERDV Unreviewed; 755 AA.
AC G2X9G3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Ras guanine nucleotide exchange factor {ECO:0000313|EMBL:EGY15631.1};
GN ORFNames=VDAG_06795 {ECO:0000313|EMBL:EGY15631.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY15631.1};
RN [1] {ECO:0000313|EMBL:EGY15631.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY15631.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS572708; EGY15631.1; -; Genomic_DNA.
DR RefSeq; XP_009657794.1; XM_009659499.1.
DR AlphaFoldDB; G2X9G3; -.
DR STRING; 498257.G2X9G3; -.
DR EnsemblFungi; EGY15631; EGY15631; VDAG_06795.
DR GeneID; 20708258; -.
DR KEGG; vda:VDAG_06795; -.
DR eggNOG; KOG2378; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR InParanoid; G2X9G3; -.
DR OMA; HIAKWVA; -.
DR OrthoDB; 4819765at2759; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 294..420
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 524..755
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 177..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84345 MW; 19ED84588893D10B CRC64;
MQQPNSANMD SLNIAIIGAT GVGKSSYIQR VLGLSRPPIS NASSVRLVVD NMTLGVTLLE
LDLEYFDMSP AHPIQWPKQI NGHIVPRVDG ALILYDVTKG GTMKELPETI AALTKAGLPA
VLVANKCDPG NVRQVDTQLV ANHDLFKSCV ATYNLSSNAP ERARACLHTV VKAAVANRKD
PQGAEPAASR RRAASTANLD TLDAPTNRPL SQQSKHSRAS SDLSLLRVLP STTEPSGDEF
NQSVSSMLRT PGIRLDRAPN DSFLDMDESD AESRNSPDDI PILQRNDEAL SDKPAKAAAG
VSFDELVDRL ISLKMSRADH NFLEVFLCLY RKFAAPGELF SSILIRLDRV RDDKTSHHLT
KTATQLRIIE VVARWVSLYP GDFARPATRR NLEDFIRHLS TEPIFCIAAR QIRQHLEHSV
VEDDDTGWAK SDDVADKAAS RVLSKEASRS MSDISVGVSS LYLDDDKMGD DRPSGSPDIL
QVDRVNSFVS LQSFDDYERE AATMEPTDVL PMNKFRYHIF MDIPEDDIAE EMTRIDWVMF
SSIRIRDFVR HVSLPIDQRA KCKSLKNVNR MINHFNHVAK WAANLILLRD KPKHRAQMLE
KFMAVAGKLR RMNNYSGLAA VLAGINGTAV HRLAQTWALV PPDRKRAFAK LGILMGTQKS
HFAYRLAWEN SPLPRIPYIP LHRRDLVSAE EGSKTFIGTD NDRINWKKFE VLGEILLPIM
KSQSTAYPNL TKLESARELI LDCRMPTDDE EIYHA
//