ID G2XGZ9_VERDV Unreviewed; 553 AA.
AC G2XGZ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Delta 8-(E)-sphingolipid desaturase {ECO:0000256|ARBA:ARBA00016939};
DE EC=1.14.19.18 {ECO:0000256|ARBA:ARBA00012019};
GN ORFNames=VDAG_09431 {ECO:0000313|EMBL:EGY19097.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY19097.1};
RN [1] {ECO:0000313|EMBL:EGY19097.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY19097.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
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DR EMBL; DS572720; EGY19097.1; -; Genomic_DNA.
DR RefSeq; XP_009656687.1; XM_009658392.1.
DR AlphaFoldDB; G2XGZ9; -.
DR STRING; 498257.G2XGZ9; -.
DR EnsemblFungi; EGY19097; EGY19097; VDAG_09431.
DR GeneID; 20710894; -.
DR KEGG; vda:VDAG_09431; -.
DR eggNOG; KOG4232; Eukaryota.
DR HOGENOM; CLU_016265_3_1_1; -.
DR InParanoid; G2XGZ9; -.
DR OMA; LYNCNYF; -.
DR OrthoDB; 294339at2759; -.
DR UniPathway; UPA00222; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF30; DELTA 8-(E)-SPHINGOLIPID DESATURASE; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 230..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..84
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 94..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 63383 MW; ED325A3AA67507A9 CRC64;
MDARKHRDLP LLSRRQVEGL IASGRTIIIV DNYVLKVDAW LKYHPGGDKA IMHMVGRDAT
DEVTVLHSPE AREQMMRYRI GRVGGRWENF LPPIQGGSFR DMATEAPEDE EQTSTSSDTD
SREASPVFDA EKPLAHRRYN TTTTNTRGHS SSASSVSSHD DDHKMTPTGF LDAQTKKEIS
LDLDRYPSLD INTQHEIVIK YRLLNKRIQA EGLYDCNYLS YAIEMVRYSL LFSGMLLFLS
RGWYVPSAMC LGIFWHQLVF AAHDAGHMGI THNFHIDTCI GIFIADFLGG LSLGWWKRSH
NVHHIVTNSP EHDPDIEHMP FFAVSHRLLG NLYSTYYDRL MKYDAFAKVM LSVQSKTYYP
IMLFGRFNLY VLSWDHLIAG RAPRHGPAWW HRWLEVVGQA FFWAWFGYGI VYRCIPTAWD
RVVFVIVSHM LQAPLHIQIT LSHFAMSTAD LGPAESFPQK MLRTTMDVDC PTWLDFFHGG
LQFQAIHHLY PRIPRHNLRR TQKLVQEFCV DVGIPYALYG FVDGNKTVIG KLAEVSRQAA
ILAECQKHVA SHE
//
