ID G2YT54_BOTF4 Unreviewed; 2112 AA.
AC G2YT54;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=NRPS6, nonribosomal peptide synthase {ECO:0000313|EMBL:CCD54958.1};
GN ORFNames=BofuT4_P162470.1 {ECO:0000313|EMBL:CCD54958.1};
OS Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=999810 {ECO:0000313|EMBL:CCD54958.1, ECO:0000313|Proteomes:UP000008177};
RN [1] {ECO:0000313|Proteomes:UP000008177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T4 {ECO:0000313|Proteomes:UP000008177};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
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DR EMBL; FQ790352; CCD54958.1; -; Genomic_DNA.
DR STRING; 999810.G2YT54; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_2_1; -.
DR InParanoid; G2YT54; -.
DR Proteomes; UP000008177; Unplaced contigs.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF16; NONRIBOSOMAL PEPTIDE SYNTHETASE ASQK; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008177}.
FT DOMAIN 784..860
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1585..1661
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2112 AA; 233229 MW; DD360E19E367EF82 CRC64;
MAMDPDQHRD SGFTALLSME GGQHSPGNGF VDLLPGQPDS EGFRAFNVKG LSFDQIFTPT
GMREEILLLS WLIVLLRIQD EGSQISYDWA YKTRENDFEH EPVKGCLSLG EVMKTSRDNV
RQVTSEISHH ITKIASSQDV AISSPVSLLL STSSLSQTSE EAIDEGVLHL ELRFTNDLLE
IRPLWHTETI LEFTATHFVE SLVDTIKLCI STPEVSIEDC LHPTSRDLNE IWRWNHQLPP
TYSSCMHDMI SERAKTLPTK VAIDSWDGSL TYGQIDQYST FLACSLREMG VKLHDVLPVC
FEKSRWTIVA VLAVMKVGAT LLMTDPTLPL ARLQNMAEQV DAKLIVTSRA QYDFSRLIVP
NGKIMVVEES TFTNSSDLPA SSPLETVPAS ALMYIIFTSG STGTPKGVML SHETYTSSAV
ARAKAVGYTE ESRVLDFAAY AFDVSIDSML LTLGNGGCLC IPSDEDRLND INGVMRNMQV
NYAGLTPSVA RILDTDVIKS LHALGLGGEA SSVRDVNTWG QHTRIVIGYG PCECTIGCTI
NSDTATGRNY VSIGEGNGAA IWITHPDNHE QLMPVGAVGE LLIEGPIVGQ GYLNDPAKTA
ASFIKDPSWL TAGHSGYAGR QGRLYKSGDL GKYDPDGSGG IIFVGRKDTQ VKLRGQRVEL
GEIESQLMAR LPSEISAIAE VITPQGLGGQ PTLVAFIGPQ QKKGQEGTDI SSIQPSEELS
QALSKANSEL TKVLPRYMIP TACIPVNYIP VLISSKIDRK RLRLFGTTVD LRDVNEETTK
TSTRDLTDLE KRLRQAWGHI LKLDAESIRI DDNFFALGGD SLAAMKLVTV CREDGLDLSV
INTFGHPTLS AMAEVVHVSS SETKTEIPAF SMISQSAESA CLEASQVCGT DQTAIENIYP
CTPTQESLFT FALKSTEVYV AQRVTCIPSH IELDAWKKAW ENVVAAIPIL RTRVAQLQEP
GLQQVILKEG ISWRSSSNLE QYLECDRNER MDLGHSLARY AIVNQPDDDN RYMVWTIHHV
VYDGWSEPLL LKAVSNALQG QNIESQAYMS DFVKYVRDTD EVAMQEFWQN ELDDAVGPQF
PRLPSRDYLP TPDANLEINI SLDRSTKFPF TMATLIRGAW ALVASQYTGS DDVVFGETLA
GRDISLKGVE SIVGPLIATV PVRVNVSRSS SIEAYLQSVQ QSMLARIPYQ HMGMQNIRKV
SQDAQHACEA GTGLVINSEP EYVGSDLGFK SGDVEHESLH FNPYPLMLAC GIRKTGFRIC
ANFDSSLVEI AQMERMLAQL KMACSQLTKD LSRRIDEVSC LPEAELNQIW QWNQTPPLSL
DKSSKRVRAD ASIRQGSTYP PAVVSWVCDP RNPSLLSPIG CIGELWLEGA FSSDEAVESP
AWLVAGSSTC GGRTGKLQPT GDIVRLLEDK SLVFVGRKEN VMPVQGHAVD ITELEAHFAK
YLPQAVRAAA AVYQPSSDDS QQTSKQELLV FVEQQLPEEG DIEVILAEHQ LVCNAPDMQS
FKATVCTKIS LSLALALKKL DKFIQDSLPS YMMPFAYIIV DKLPKEKKNV DHDLLNLLAS
NIPRSVLSDL RQGFKEVWSN NSAKQNLTNS ESILQAAWAN VLGIPSEKID VDDNFFRLGG
DSVMAMKLVS GLRVQGHVLT VADIFQHMRL GDAAKVLKVD RASANKVQPY KPFSTLNNPD
INTFLSQVVR PKLADPNWTI QDVCPVTDSQ ALDIRGTIQS LRTSVQYTML YFDESIDRLQ
LFRACKALIQ NHAILRTVFI EHESNFFQVV VGELDNPEIN TLRAEDIEQC ATEVCTRDIE
SGFHLGSSFL RLLHAEDNNG KECLIIGLSH ALYDGVSLPL ILRDLEVLYK GEKVVDFEPF
SAYMARICDK HVQETAINYW RNLLDGSSLS VLNGKSTETT DKAIFQTKSV DISRRPEEIT
AANLLTAAWA LVLARRLQKP DVTFGSITSG RNIDLAGAEN VVGPCYQFTP TRVSFESEWT
AMDLLRFVQK QSAESAAYDF LGFDKISKQC TQWSSDTETQ FFDSIVHHQD WDDFDTMPFA
GRECKVDILN PHGDAATPVK AVTFVKDGQM HVGVVGSEKD TVFVNTALDE LAAAIQELAN
SRSELLLDGQ MF
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