ID G2YW77_BOTF4 Unreviewed; 4695 AA.
AC G2YW77;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=BcNRPS3, nonribosomal peptide synthetase {ECO:0000313|EMBL:CCD55875.1};
GN ORFNames=BofuT4_P150070.1 {ECO:0000313|EMBL:CCD55875.1};
OS Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=999810 {ECO:0000313|EMBL:CCD55875.1, ECO:0000313|Proteomes:UP000008177};
RN [1] {ECO:0000313|Proteomes:UP000008177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T4 {ECO:0000313|Proteomes:UP000008177};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
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DR EMBL; FQ790358; CCD55875.1; -; Genomic_DNA.
DR STRING; 999810.G2YW77; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000092_1_0_1; -.
DR InParanoid; G2YW77; -.
DR Proteomes; UP000008177; Unplaced contigs.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF16; NONRIBOSOMAL PEPTIDE SYNTHETASE ASQK; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008177}.
FT DOMAIN 794..874
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1901..1977
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3011..3087
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3561..3637
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4120..4193
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 779..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4586..4608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4695 AA; 516411 MW; B0A7E9FCA74AC4C8 CRC64;
MDSIIPNTTF PYLDTAYRNV ADSQVSKGEL NRNRSGNDSE PHLKTISKIF SSGEWDFDLS
IIQESYAQFV AAFTGHDEVA FYTYSDISSN TPTADNLQEC GIIHARLTEE PKNDQKIHPS
ISWRFVQDIP RSMESFDFAL HVTKSRDMKS LSDITPFTII ITVDDASVIE STLSYEPSLL
SDSDAPHIFG AAVSYLRCSP SSDAETVANE SVLNFPPLIR PPSFLEDERG SDLQNQKALL
HSAFERRVAQ HPNRVALDFL QSQDSESKSP VRRTFTYSEL NEITTSLAEY ILLSRGEQES
GNSKFVPVLL STSAELYIAY LAILKAGLAF CPLPIEAPPQ RLKDIHEDLM PQIILGSEQY
RHKLSAISSD SMKWIDIESF IHMRTRAGIA TQNPPSFRVV ASPEENDVAY IMYTSGSTGK
PKGVQITHLA AACSIASHAI TSKLPPSPEG IPRWFQFAAP TFDPSLMEIF VTFSTGATLC
SASRDLTLTD FEAVVSELQA TVMMATPSMA ALLRRSKLTS LKSLWTMGET VLRKNIEDFA
RSPSPDQSSE LCNAYGPTEA AINCTLIPNF HPEDRGSIIG PALPTCSLFV VDTGSDSIKP
VPKGFAGELA IGGPQVSVGY LNRPEQNAKA FIVSPEFGRL YLTGDKARIV TDRSGQHVVE
FLGRMDTSQV KLSGRRVDLG EIDTVVASSA GIKEAVTVSY KRFANQAGSE EAVCFIILDA
DTTKEDVEAR CRENAARLLP SYMCPSKYFV LSKMPRSLAG KIDRKSLSAM TEALWNEDSS
KPSNLLQNGE DASSSNSQGQ DEIMRLILNL LSELVGSTAN LTSNTNLFSL GIDSLKAIRF
LQLARDAGIT ELSIADVLGG ATPLKLRNII VERRKNATGE TPTHEVIGTP ISFDDFEAKH
RPICSESLGI SSQDIAKILP TTATQSGMLA SFLRSSKDNK HYIHNSVHHI NPSVDISRLK
DSWIATVQRH ESYRMVFVAI DDALSPFAQC VLKESSALDV PSWKEVTCES DDPQTVVKCI
QSTLRDAENE MLLDRPPYQM TLIQSPTKTF FTFSVFHAIF DGASLQLLFD EVDLVYRGSD
IPRRTEISTA VSMHYGSDPT QTIEFWSSQL KDCDPVPFPS LTGLKPETMT KLPLTSSIKA
SIGINDLRDG AMNCSTSPLS ILQAAWALIL ATYKDSIHSS TFGSVISGRL DEDSKVCMGP
TFTTVPINIP AQLLESKATS VSSILHAIAK INAESLAHLQ IPLNSIVAPN GGLYYDTLLA
FQDFSTGTNH SELWSKVDYP AMANDFAVMI EIWPEVDGSL RLRATYTDEF LNDESATLML
QQFSDLISFV IRNPKNSYMD GRYATAPSIY PQVMSTELTG ASALLHTEFE RNTKMNPDDI
ALIFMNDFTA QDPAANVQWT YAELDHRANR LASYLVQRYG PLEDKVVPFS MYKSPELYVA
ILGILKAGGA WCPIDPTFPA SRRHDLIVRT DANMLLVAND TVSQDAQAIP QGVALIDISE
NNVTNSTFSL DETKPSSLPI IRSNSMAYLI WTSGTTGLPK GVQVHHSAAA TAMQSLKESI
PVSRSGAVRC LQFSQPTFDV FVQDLFYTWG LRGTVIAAPK DVMLGSFPDL ANITNATHAH
LTPAFATIVS RVHCKTLEIV TMIGEALPQP VADDWSQNML AYNTYGPAEV SVVSTVKQFG
GFENPFKSTN VGLPLPSVGV FVLNNERVVM RHGVGELALS GPQVARGYWK DLAKTEEKFH
WNDSCGAHIY MTGDIVRQLH DGSLEFVGRR DDLVKINGMR VELSEISFAL SHCHPDTEQA
VTMLMARPDR PTKVLVTFLS TPSIPAQDLL ITNNRAVEVA KAAMAVSKAN LPEHMIPSVL
VVLNRIPVTA SAKIDRKALS GAYEALDLES WESNFTSTQD TVWTDEEERL LEHFATFLGT
ESKNFRSNSR LATLGFDSIA AVRFTARLKA AGYKVSAAHM LHCQTIADLC NLFNKPASNS
TCLDSSSRLL DVFHRKWFPK VAETSAISDK GFAVCPTLPL QENLLSETFR NYEYYWSNHF
FDLSDDIDLE LLKAAWFKVA QNNEALRIGF LPTASVSVKA NSGFGASTFL QLIYEKPSVD
WSVVKVMNED FATSAKTHAQ QIARKHQSGA FINSPWAVVV FERDNVRTMM LSIHHTIHDG
PSLKFIIDDL HAAYLSQEGL LNPRYQIREA IALSFMRRTS PQEDMVFWKN ILKDFVSEAD
DSVEKMAPEN KSRTYNTISI PLSIPISKLQ NTAQEFHCSS ANSILRAAWA CIVSDFLETD
QKIVIGEVLS ERLASSSLED IIGPLVSLTP VPIFTSGTAR EIVSKHDSMN IAAYSHRDAN
PGMLRKLIGR PKSQPLYPAV FVFHPRNTES EHEHELWNEI EDFLGLNVEH DLTLNVEENA
HGGFDLVVSV EAGVLDIPGV EVLTKQLDAL VTAMISHPDT PIQELTNYFP TELIAISKYR
EMKLDPVVDL NNPLCWFEHW AETHPDWAAA EIAESIGQNS SIIHTWSYGR LNHEANSVAT
FIASHGIHNR MIGMCLGRTL TAFAVTVGIY KSGNTYLPID ESLPIERKAF LLKDSNSAIF
FSEETVDFVP EGCLSVNVNC DQYQSDSEVA LKVQKSKDSV AYLLYTSGST GNPKGVLISC
GNLTSFCEAQ SEFICEYVPA TRVLGGVGRF LGLASRAFDV HVAEMFLAWR HGMSCITGVK
SMLLDDLPMA LQELKITHAG FVPSLLDQCG LIPSDVPLLR YLGVGGEKIS QRTLETWGDS
ESVTLINAYG PTEATIGCAS SPIVNSKVNM RNVGRPLGDT VAHVLIPGTL TYAKRGVEGE
LCLTGSLVGI GYHNRDTGAF VENFHGGIMY RTGDLVRLMP DDTIEIFGRS DDQTKIRGQR
LELGEVSEAV RALLPAGSNV SSLITKHPEL SRMQLISFVA SNTKAAGIDE KVEMLDTFEQ
INVSIRAGCR ERLPGYMVPD VVIPINFLPL AAMSGKADVK QLKALFASIP LSHLLSAEKG
QSTGNKTATV RELDEQEIAV VGILKSVVPA TSADFTPSTN IFEVGVDSLV AISLSTLMRK
AGYTCSVADV LSISTVEELA LLPRADTTPE QAAKNKENAL KKIARAEAAF RESSLGKKSG
MNVETVRPCL PVQEAVVARS LNKEAGALYV NHITFELVSE IDISKLSQTW KSCATANEIL
RTCFCQINDD ILQVVLKNES FDMPWAEHIY SKSSKYCTPD KMQDLISLDI MQNIENTPPI
RLNIFTEGSS KSILLISMHH ALYDAESLAV LMQDILMRYQ GIPTPERPSA GALVKYVASQ
DELAAKNFWV KKLGDYSHPP PGNNDATEEE EQIEAQISTR ILKTNLSALE AFASRLHVTL
PSLTQAIFGL AMAKVLSIND FVFGLVLSGR TVPVPDIEKL LAPTITTVPQ RIDLRKNDAT
ILDILTALQK SSGQMLQFQH SSLRSIHKWV EADRPLFNCL FSFMKTGEED ADNDLWKLLD
SYMPPDYPFA VEFEARHASN DLVIRAGYTS EFGSASTVDN LLEMIEVLID TISKNDNISI
KSLGIQSNHI ASSSAEILDD GEEWPEEQTI KNVLLGLGDF ASGDVSRNST FFRLGIDSVI
AIRFAKELRR VGLQVSSSDI GRYPSIAALA RAVSSKSKTH AVAKPAAVKP SSLFDQHKAS
IPLLADDDKI TEIYASTPLQ TGILTQTVAT GGNLYLHHPA IKLSANIDIA RLKNAWTSVI
ETHDILRTTF HYFEGATHPW VAAVHAKPGI QWIEEQASGW IDKSIEKIIE STSFPTPDSF
SHTPLKITIL HSSFMKVLVL SIHHSLYDGF SLPLIFDYLS SAYSSGISNP PTTPFSEAAK
LITERQGTSV EFWLNRLDNY QSISLPSSTI PAETTSLAQM TIQMPVAEIL LRCQEMNINL
QSAALLAYAK TLFCFVKRRD IVFGHVVSGR SLPLPEVEQI LGPLFNTVPF RVVLDNPVLG
NQDYARQIQD VVIEGQENQH ASLSTIQKFW RQKNVFTGDA LLDALFVFQK VGGVDGATKE
KLWSVMEVGE SRDATEYGLN VEIEQGIDEV IISAGSPAGR INAEDLNLIC KTFDQALRDI
LENPQRSVVA YPEGLQGLPL ESTPKSKIEN AEDHSDIADA PVLEVVRAAL AEVANLPTDS
VTLHTNIFSL GVDSIAAIRV ASICRRRGVP ISVADILQGN SLGGIVRILV AKSKTSTQQQ
DATTELLSPE SKANALSLLK YPKDTVEEIL PAMAGQEYHL ASWLQSGRTF YEPTWAFQAR
EKIDTARLRT VWRDLQLRHP ILRTVFTAPT PESSYQIVLK PEIINEGNFT VIPTRSADED
LIAAVKRQVH HWAQRPSTLF TPPINLCVVQ TAKADAVLFR IHHSLYDAWS MMALIKEVCT
LYTQPSSLLP DTPDFISFVK HTHSSLSSAS SLAAQKSYWE SALRAAQPTI LKPTAQSPAN
ENDQDMTQTF LWLKNAIPHL RALHTLARAH ATSINTILML AFARALARLT HTTHPTFGFF
QVGRSSDFDG AATVLAPTVN LLPVSVAVSG GAETDILQDI QRDMSQRVAW EQSRLRDVVR
WTQGRGQGTE TRKSSQPLFN ASLNLLFHKP GEDSPPPSSS PPQSAELLAP LPIGVPTDFS
APRRISGDTP VQNLDAAYLA PRNVFVDVGE GADDCVDFGV KVDRVLMDEV EIQKFVEGIA
REVEGIRRVL ARRAV
//
