ID G2Z0Y6_FLABF Unreviewed; 737 AA.
AC G2Z0Y6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=GTP diphosphokinase {ECO:0000313|EMBL:CCB69533.1};
DE EC=2.7.6.5 {ECO:0000313|EMBL:CCB69533.1};
GN Name=relA {ECO:0000313|EMBL:CCB69533.1};
GN OrderedLocusNames=FBFL15_1468 {ECO:0000313|EMBL:CCB69533.1};
OS Flavobacterium branchiophilum (strain FL-15).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1034807 {ECO:0000313|EMBL:CCB69533.1, ECO:0000313|Proteomes:UP000009186};
RN [1] {ECO:0000313|EMBL:CCB69533.1, ECO:0000313|Proteomes:UP000009186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL-15 {ECO:0000313|EMBL:CCB69533.1,
RC ECO:0000313|Proteomes:UP000009186};
RX PubMed=21926215; DOI=10.1128/AEM.05625-11;
RG 1:IP;
RG Microbial Evolutionary Genomics,F-75015 Paris;
RG France 2:CNRS;
RG URA2171;
RG F-75015 Paris,France 3:Unite de Virologie et Immunologie Mol.;
RG INRA,78352 Jouy en Josas Cedex;
RG France. 4:Unite de Mathemathique;
RG Informatique et Genome,INRA;
RG 78352 Jouy en Josas Cedex;
RG France. 5:CEA/Genoscope;
RG Evry;
RG France;
RA Touchon M., Barbier P., Bernardet J.F., Loux V., Vacherie B., Barbe V.,
RA Rocha E.P., Duchaud E.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT branchiophilum.";
RL Appl. Environ. Microbiol. 77:7656-7662(2011).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; FQ859183; CCB69533.1; -; Genomic_DNA.
DR RefSeq; WP_014084000.1; NC_016001.1.
DR AlphaFoldDB; G2Z0Y6; -.
DR STRING; 1034807.FBFL15_1468; -.
DR KEGG; fbr:FBFL15_1468; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_2_10; -.
DR Proteomes; UP000009186; Chromosome.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CCB69533.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009186};
KW Transferase {ECO:0000313|EMBL:CCB69533.1}.
FT DOMAIN 401..462
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 737 AA; 84012 MW; 669DBB3D14AE8D4E CRC64;
MNEIDIEKEN KAIAQEYKEL LRISYQTLTD EDKKLIRKAF DVAVDAHKEQ RRKSGEAYIF
HPIAVAKIVA SEIGLGATGI AAALLHDVVE DTPFTVQDIE TMFNPKVAQL VEGLTKISQV
KKDLNISMQA ENFRKMLLTL NDDVRVILIK LADRLHNMQT MDSMAAYKQT KIASETLYIY
APLAHRLGLY NIKTKLEDLG LKYTEPAVYK DIVSKIKETK EEQDAYIKDI SDVLKKSLDE
EGMDYIIKGR PKSVYSIRRK MKAQNVTYDE VYDKFALRIV YKSNPHDEKF LAWKIYSIVT
DHYRPSPSRL RDWISSPKST GYEALHITVM GPKGRWVEIQ VRSERMDEIA EKGYAAHYKY
KNGGEESGLD VWLNLLKEAL ENSESNAVDF VEDFKMNLYS KEIYVFTPKG DIRSLPKGAT
SLDFAFSIHS EIGIKTRGTR VNGKLVPLNY ELKSGDQVEI ITSTSQKPTS HWLEYVTTSR
AKNKIRNVLN ENTKKIAEEG KEILTRKLRH LKVTLNEKTT NELVNYFKLK TSLDLFYRAG
IGALENQALK DYAAKKSNTL FNFFKNKIKR SPNNSDIDFS KNTPTQNYDM LVFGAEQDKL
DYKFSTCCNP IPGDTVFGFL TINEGIKVHK HDCPNAISLQ SNYAYRIMAA KWVDSTQQEF
KAILNIMGMD TLGLTNELTK VISNNMHVNI QSISLSGDAG IFNGQITVIV QNNTILKKLI
DNIKKIDGIE KVVRVYH
//