ID G2Z143_FLABF Unreviewed; 451 AA.
AC G2Z143;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:CCB69606.1};
DE EC=2.3.3.10 {ECO:0000313|EMBL:CCB69606.1};
GN Name=mvaS {ECO:0000313|EMBL:CCB69606.1};
GN OrderedLocusNames=FBFL15_1541 {ECO:0000313|EMBL:CCB69606.1};
OS Flavobacterium branchiophilum (strain FL-15).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1034807 {ECO:0000313|EMBL:CCB69606.1, ECO:0000313|Proteomes:UP000009186};
RN [1] {ECO:0000313|EMBL:CCB69606.1, ECO:0000313|Proteomes:UP000009186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL-15 {ECO:0000313|EMBL:CCB69606.1,
RC ECO:0000313|Proteomes:UP000009186};
RX PubMed=21926215; DOI=10.1128/AEM.05625-11;
RG 1:IP;
RG Microbial Evolutionary Genomics,F-75015 Paris;
RG France 2:CNRS;
RG URA2171;
RG F-75015 Paris,France 3:Unite de Virologie et Immunologie Mol.;
RG INRA,78352 Jouy en Josas Cedex;
RG France. 4:Unite de Mathemathique;
RG Informatique et Genome,INRA;
RG 78352 Jouy en Josas Cedex;
RG France. 5:CEA/Genoscope;
RG Evry;
RG France;
RA Touchon M., Barbier P., Bernardet J.F., Loux V., Vacherie B., Barbe V.,
RA Rocha E.P., Duchaud E.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT branchiophilum.";
RL Appl. Environ. Microbiol. 77:7656-7662(2011).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
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DR EMBL; FQ859183; CCB69606.1; -; Genomic_DNA.
DR RefSeq; WP_014084073.1; NC_016001.1.
DR AlphaFoldDB; G2Z143; -.
DR STRING; 1034807.FBFL15_1541; -.
DR KEGG; fbr:FBFL15_1541; -.
DR eggNOG; COG3425; Bacteria.
DR HOGENOM; CLU_008065_3_2_10; -.
DR Proteomes; UP000009186; Chromosome.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 1.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CCB69606.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009186};
KW Transferase {ECO:0000313|EMBL:CCB69606.1}.
FT DOMAIN 2..173
FT /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01154"
FT DOMAIN 226..414
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
SQ SEQUENCE 451 AA; 51183 MW; 81E1B6E8BA927DB3 CRC64;
MNVGIDSISF DIPQLFLPIK TLAENRNIEP DKLIKGLGLT KMSFPDVYQD VVTFASNAVW
KLIDKEQINP NEIDRIYVGS ESGVDSSKPI ASYLISNLES KLGIGVFKNC DVVDMTFACI
GAFDALQNTL DYIRLHPDKK AIVVATDNAK YDLNSTGEYT QGAGSIAMLI TSNPRILKFE
SVVGLATQGV FDFFKPRRII SKNEITNQSD NPEWFGVLEQ EVAIYKEQPV FDGQYSNTCY
IQRITEAYFN YKQKSGQNGP IYKNWTNVLM HLPYAFQGRR TFVEIFAQEN PNVLLNPNDP
TYKEDIKGIA KSEDYLNFVN DKIRPSEIAS GQIGNIYTGS IFLGMLSTLC YHFKENNDII
NHKMGFIAYG SGSKSKVMEA QVMPQWQSVL QDIQLFETLD QCHEIDFETY TVLHKKERKE
AVIAPKNEFV LDRIEKENPV LVGARYYKFI D
//
