ID G3ADY1_SPAPN Unreviewed; 426 AA.
AC G3ADY1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=3-deoxy-7-phosphoheptulonate synthase {ECO:0000256|ARBA:ARBA00012694};
DE EC=2.5.1.54 {ECO:0000256|ARBA:ARBA00012694};
GN ORFNames=SPAPADRAFT_57769 {ECO:0000313|EMBL:EGW34705.1};
OS Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=619300 {ECO:0000313|Proteomes:UP000000709};
RN [1] {ECO:0000313|EMBL:EGW34705.1, ECO:0000313|Proteomes:UP000000709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-27907 / 11-Y1 {ECO:0000313|Proteomes:UP000000709};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC Evidence={ECO:0000256|ARBA:ARBA00001370};
CC -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC {ECO:0000256|ARBA:ARBA00007985}.
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DR EMBL; GL996499; EGW34705.1; -; Genomic_DNA.
DR RefSeq; XP_007372117.1; XM_007372055.1.
DR AlphaFoldDB; G3ADY1; -.
DR STRING; 619300.G3ADY1; -.
DR GeneID; 18872188; -.
DR KEGG; spaa:SPAPADRAFT_57769; -.
DR eggNOG; ENOG502RXNY; Eukaryota.
DR HOGENOM; CLU_033451_0_0_1; -.
DR InParanoid; G3ADY1; -.
DR OMA; NLTKYNH; -.
DR OrthoDB; 1981983at2759; -.
DR Proteomes; UP000000709; Unassembled WGS sequence.
DR GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006218; DAHP1/KDSA.
DR InterPro; IPR006219; DAHP_synth_1.
DR PANTHER; PTHR21225; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE; 1.
DR PANTHER; PTHR21225:SF0; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED; 1.
DR Pfam; PF00793; DAHP_synth_1; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Reference proteome {ECO:0000313|Proteomes:UP000000709}.
FT DOMAIN 203..376
FT /note="DAHP synthetase I/KDSA"
FT /evidence="ECO:0000259|Pfam:PF00793"
SQ SEQUENCE 426 AA; 47410 MW; 87993F542C853648 CRC64;
MSLQPRIKSP LSRTLEKSLV IETSESVNTT DTEVESPVAH SYAPEWEYHQ TATKSSNTTN
KGNIPIPQPE VMQKVLYPIT PQLQNKIFND RTNVNSLLSD GKKPLLVITG PSHIKDTNQI
KACAQYLSLK QGNSITSSDY LPSEIKSIFH DPAELSNLHL ALRTNLTMYN HAYTSPQSQS
IRTFEIDKGI PKCRSLLREL SQYAPLVSEF VDTLTPQYLA DFYSMGIVGP TLIESQLHRE
LASGSSYAVG FSAGEKSDML DHKLTSCLDS MYATSQPHQF LSITKYGTVA VVGTTGNSDT
FVILPLGDDI TELVAKVNSY KNLQGKTVKL LLDIGRVSND DYETKLITLK SVLDSEVRDQ
ILGVMIDSGD HYVPYDYQVD DREDVESLFT LVDRASSESL SFAPNSNYEY FINANNLLLE
LNNLNK
//
