ID G3AIA9_SPAPN Unreviewed; 981 AA.
AC G3AIA9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Calcium permease {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPAPADRAFT_133434 {ECO:0000313|EMBL:EGW33678.1};
OS Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=619300 {ECO:0000313|Proteomes:UP000000709};
RN [1] {ECO:0000313|EMBL:EGW33678.1, ECO:0000313|Proteomes:UP000000709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-27907 / 11-Y1 {ECO:0000313|Proteomes:UP000000709};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; GL996500; EGW33678.1; -; Genomic_DNA.
DR RefSeq; XP_007373262.1; XM_007373200.1.
DR AlphaFoldDB; G3AIA9; -.
DR STRING; 619300.G3AIA9; -.
DR GeneID; 18869747; -.
DR KEGG; spaa:SPAPADRAFT_133434; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_001583_0_0_1; -.
DR InParanoid; G3AIA9; -.
DR OMA; PQWDMIT; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000000709; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000709};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 845..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 908..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 936..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 257..313
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 547..731
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 806..954
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 110796 MW; 077FC03B673471C9 CRC64;
MRSSSGTNIS TPGSLRNRSA SKSRTASRPS LKRMGSVSTA HTPKLIYSVD DDINDRIDED
MLDILSEEPI VKTQSDRDYL EGYNDALRAL LQRKTRSPMI QPRSTPDLRR SEEEERRSGS
VSGVKSSDDV QKIEETIAQD LLRAEENIRI LEEIDDSRRA SIGDSVNDTT ESIHDEGDLL
DVPADEEVDD GASLHSVESL NLRERQDAIN STHPFGIKIW KPSLYKKKRS VAARAEEDIH
DFDPRKPTAR IYWGVTLTNY LWALTAGLFI YIICLIGAFF VFVFSGFALQ QKSRPYVKLF
LKLGRFWLYP FGKFVMLNKD ENYIDEDQIF GRTINEFHQW RLQEEGRLFF APPRRNTNST
GESRPLIKDH KGRPLRDAYS TLDEGNSSSI AEQDENIEDD QDNIKMRLFG RGRWSPGRLA
FYVYFYGILQ PLSYLIGLLC WLIVFTIPMS NITGTINDHL RRHPLALDFE LEKEYYQRME
DPVQKKKKKQ QRILLCTYRC CGFHYYKYTI DGTNIFFINL LAVVIFVIFD FLVLKEVLDI
DAWFTNSTVI FCASLFSIIP LAYFIGQAVA SISAQSSMGV GAAINAFFST VVEIFLYCVA
LKQYKGKLVE GSMIGSILGG VLLLPGLSMC GGAVRRKTQR YNPRSAGVSS TMLLFAMVIM
FAPSLFYQIY GAYEIKCHTC DITLGGDDCT KCRFIQPSFT LDALYYNVLK PFSLIVAIAL
FVAYICGLLF TLRTHASLIW ATHENKRHDD SFMRSPSMIS LNATPRQTPR QEPVPPKMSA
LPPSAEHLDD EGTGGHDAPN WSRTKSTVIL LGATLLYAII AEILVDTVDA ILVDFPINPK
FLGLTVFALV PNTTEFLNAI SFAIGGNVAL SMEIGSAYAL QVVLIQIPCL VLYSMVQNFT
NVDQVFPLVF PRWDIIATLI SIYLFTYIYA EGKSNYFKGV ILILIYCVVL IGFWFNDIME
DLNDEYSGLA QMIKFSLGGG M
//
