ID G3APQ9_SPAPN Unreviewed; 1049 AA.
AC G3APQ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN ORFNames=SPAPADRAFT_55732 {ECO:0000313|EMBL:EGW32230.1};
OS Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=619300 {ECO:0000313|Proteomes:UP000000709};
RN [1] {ECO:0000313|EMBL:EGW32230.1, ECO:0000313|Proteomes:UP000000709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-27907 / 11-Y1 {ECO:0000313|Proteomes:UP000000709};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR EMBL; GL996502; EGW32230.1; -; Genomic_DNA.
DR RefSeq; XP_007375506.1; XM_007375444.1.
DR AlphaFoldDB; G3APQ9; -.
DR STRING; 619300.G3APQ9; -.
DR GeneID; 18871964; -.
DR KEGG; spaa:SPAPADRAFT_55732; -.
DR eggNOG; KOG0207; Eukaryota.
DR HOGENOM; CLU_001771_0_1_1; -.
DR InParanoid; G3APQ9; -.
DR OMA; GGKFMVC; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000000709; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000000709};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 292..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 326..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 365..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 543..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 925..946
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 952..973
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 51..117
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 1049 AA; 114389 MW; 5A3443CD1ED0BC92 CRC64;
MPSMPQPKTV KYAPVLHNDS SIDITVQEME HSSSVFSPLP SPYSPTLSSA SSTTLTIQGM
TCGACSASIT ESLKSTPGVI DASISLITEN GLITHDSSII TAQQIKQTIE DCGFDAQIQS
STNIMKEQPS SRSDIQDEED TNLQIVGISS AVDVSALRYN IEAYLHSCPG VIEFVLVLRN
NSNDITQEDQ LEQSEDSTVL TDEISIKFQP SAVGIRDLVD GLNVIEPGVE FVVMNSLDQS
SAAQLKLLSK VKDIEYWRNN CIKCVIFGLP CVVLEHVEQM EFWRSKLVFP GLFWVTLIQF
VLASYIQFIL GAVFIKKFIA FVRNGFKGAS MDVLICISTV VSYLFSLTTI TLSVWYGEKE
HPPKVLFDTM VMIILFISLG KLLENKAKGA TSTALSKLLS LTPSTCVIVK DVADYQLFMQ
QQSEKTSAGA IQDFATRTIS IDLVQPNDIA IVLPGGKIPA DGTIVFGETE IDESLITGES
LPVHKLRGDP VIGGSVNGPH LIHIQVSKTG KKSQLQQIIN LVKDSQVNKA PVQRYSDYLA
ARFIPAVILL SIVTFILWSI VCYTIHPDKL PKIFVKDANG KLFVCLKLAI SVIVVACPCA
LGLAAPTAVM VGTGVGASNG VLIKGGDILE KATGINVILF DKTGTLTTGE MSLVSATPKI
ENLKLTVKDW WNLIGSVECN SEHPTGRALT KIAKNQLNMN FDEDQFDTII DEVKVVTGAG
IHANVQLPSG DKYNVQIGNH KLIETLCPQF LPDVQKLNLD NSNNTLSHVI INNQYCGYIE
LKDTLKDGSW DVVHYLQRQG YIVGMVTGDK RGAAWKIGRE VGIPESNIFY EVSPIHKDAV
ITDLKNRLGG NDNVKVAFIG DGINDAPALA NADIGMAISS GTDIAIESAD VVLLGSSKKQ
QTDLHGVINA LQISNATFTR IKVNFVWAAG YNFLMLPFAM GCFLPLNVML PPIAASAAMM
LSSVSVVLSS LFLKNWKSPV ISSGARGKED LEAGTSTFNL KTGTLEEFNE VKRTRGFRIG
RLFSMFKFHK RETKFVNHEY ELVPTQSRN
//
