ID G3APT8_SPAPN Unreviewed; 317 AA.
AC G3APT8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Xylose reductase {ECO:0000313|EMBL:EGW32258.1};
GN Name=XYL1.2 {ECO:0000313|EMBL:EGW32258.1};
GN ORFNames=SPAPADRAFT_61339 {ECO:0000313|EMBL:EGW32258.1};
OS Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=619300 {ECO:0000313|Proteomes:UP000000709};
RN [1] {ECO:0000313|EMBL:EGW32258.1, ECO:0000313|Proteomes:UP000000709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-27907 / 11-Y1 {ECO:0000313|Proteomes:UP000000709};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR EMBL; GL996502; EGW32258.1; -; Genomic_DNA.
DR RefSeq; XP_007375534.1; XM_007375472.1.
DR AlphaFoldDB; G3APT8; -.
DR SMR; G3APT8; -.
DR STRING; 619300.G3APT8; -.
DR GeneID; 18873849; -.
DR KEGG; spaa:SPAPADRAFT_61339; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; G3APT8; -.
DR OMA; IYRISAW; -.
DR Proteomes; UP000000709; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF218; NADPH-DEPENDENT ALDOSE REDUCTASE GRE3; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000709}.
FT DOMAIN 13..299
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 47
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 109
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 76
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 317 AA; 36324 MW; 8A95AB6AB4D457AE CRC64;
MSFKLSSGYE MPKIGFGTWK MDKATIPQQI YDAIKGGIRS FDGAEDYGNE KEVGLGYKKA
IEDGLVKRED LFITSKLWNN FHDPKNVEKA LDRTLADLQL DYVDLFLIHF PIAFKFVPLE
ERYPPCFYCG DGDNFHYEDV PLLETWKALE ALVKKGKIRS LGVSNFTGAL LLDLLRGSTI
KPAVLQVEHH PYLQQPRLIE FAQKQGLVVT AYSSFGPQSF TELNQNRANN TPRLFDHEVI
KKIAARRGRT PAQVILRWAT QRNVVIIPKS DTPERLVENL AVFDFDLTEE DFKEIAALDA
NLRFNDPWDW DHIPIFV
//
