ID G3AQ55_SPAPN Unreviewed; 406 AA.
AC G3AQ55;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Metacaspase-1 {ECO:0000256|ARBA:ARBA00016994};
GN ORFNames=SPAPADRAFT_140835 {ECO:0000313|EMBL:EGW31402.1};
OS Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=619300 {ECO:0000313|Proteomes:UP000000709};
RN [1] {ECO:0000313|EMBL:EGW31402.1, ECO:0000313|Proteomes:UP000000709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-27907 / 11-Y1 {ECO:0000313|Proteomes:UP000000709};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- FUNCTION: Involved in cell death (apoptosis).
CC {ECO:0000256|ARBA:ARBA00003621}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family.
CC {ECO:0000256|ARBA:ARBA00009005}.
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DR EMBL; GL996503; EGW31402.1; -; Genomic_DNA.
DR RefSeq; XP_007376180.1; XM_007376118.1.
DR AlphaFoldDB; G3AQ55; -.
DR STRING; 619300.G3AQ55; -.
DR GeneID; 18870323; -.
DR KEGG; spaa:SPAPADRAFT_140835; -.
DR eggNOG; KOG1546; Eukaryota.
DR HOGENOM; CLU_029389_0_2_1; -.
DR InParanoid; G3AQ55; -.
DR OMA; ERCSWCG; -.
DR OrthoDB; 1077459at2759; -.
DR Proteomes; UP000000709; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.12660; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR PANTHER; PTHR48104; METACASPASE-4; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022807};
KW Reference proteome {ECO:0000313|Proteomes:UP000000709};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 110..397
FT /note="Peptidase C14 caspase"
FT /evidence="ECO:0000259|Pfam:PF00656"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 45099 MW; 12DFAB4B6FD585BA CRC64;
MFPGQSNRSN QGRDARDHGY DERYERDNQQ GYGRVEAGHG SYGRQESYGR QEEGYGRQKS
HGRQEGYGGQ ESGAGNYSRP DGRRYSRPSA SSQSFGVGDY QYQYSQCNGK KKALFIGINY
LGTKQQLNGC INDCHNVQEF LLTQGFKKDD MVMLTDDSKS VRAIPTRQNI IDAIQWLVKN
AQPNDSLFFH YSGHGGQTED KDHDEADGYD EVIYPLDFEK AGFIDDDTLH QLLVNPLPKG
TRLTALFDSC HSGSVLDLPY MYSTKGVIKE PNLLQEAGEG LLETVKAYTQ GDSKAVISGI
MGVAKSFMNK DRASEANEKT KKTKTSPADV ITMSGCKDDQ TSADAKEGGQ STGAMSYAFI
SVMKKEPEQS YLSLLQNMRS ILSSKYSQKP QLSSSHPIDT NLQFII
//
