ID G3B6Y6_CANTC Unreviewed; 1056 AA.
AC G3B6Y6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=CANTEDRAFT_106041 {ECO:0000313|EMBL:EGV63050.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV63050.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; GL996524; EGV63050.1; -; Genomic_DNA.
DR RefSeq; XP_006686843.1; XM_006686780.1.
DR AlphaFoldDB; G3B6Y6; -.
DR STRING; 590646.G3B6Y6; -.
DR GeneID; 18245859; -.
DR KEGG; cten:CANTEDRAFT_106041; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000000707};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..321
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 598..1007
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1056 AA; 120583 MW; C80B533901CC8BCA CRC64;
MSDPATLITQ FVTFSGAEDS ENAAKYASSL ADLISTNKLS FLQFIQLLGS RITSSIDEDR
TKGMRCLAAV LHEITSSSSA LSKHDINVLV DFLLTKFSDK PCFADVIKAL TNILHAKAFS
PSLNDNLVKI LRKVVDEYDS SVHLARGRYE VFALLQTALT RFRDAITTRP ALHDLYVQAF
LHVSNGEKDP RNLLISFDLN KNINHYFRFE VATNELHKHF VEELFDTCFC YFPISFRPPP
NDPYKITSEQ LKTSLRSTLT SQFLFAKDLF NNLFEKLAST NPVIRNDVLL TLLSAVDSFH
EDTILEYWET IWNGLKFEIL HSENTNIFSV SNDRFIPENI MDLADSDENK SLYLVLEILS
RMATRLDDED GLLPGITSDL KEYLSITSKV FMKAVILLSS MATASERGFN YIQQFIFQSE
NLGKFISGFD DTDDNMETDI SLTVARQRDL IDAFGYILIS YQVLSSSLPN ASFFFESNYL
SQVKDSLVVF LGQLLQASST IEKTLKCKII QQYIKLIQLR RFLSYEEKHV IMELLNDMFF
ELIEEAKPDD LIVDEIMKGL INLTEDGSDQ NNQLIVDVFL PQVLQQIDPQ NQKLSKYVEV
LDSVVVSSQL LEVVSIRLVN RLSNDRDFNS KIIELLGSLV MKVQKRSQFL MNSWFKGIVP
KLLNQAAEVE ASGVNNSDNW HYLELISVLL GFVIKYYDSP KHQGILDDFQ SAFYKNKAKS
GLKLSGYTIL EVASPMVLVF NNVLSNIDKS TNLSIQLEDL VRLIETTSNL RDPILKVNYL
QHLCLLVNKF YKDDDSLQPV VEKLYDLQQP SNFEISVWII KALMLRLSKV GIEYLTKLLE
VLDHDASQAT IVLRSFDIIL RDLKIFSPNK ELPKGSKIIS KVNHLNTRSL YKQQVFNIVL
AKVLQQPENE IHLQLLAVLT KNIDSHVLKS RINDIIPLTI QSIQLNTLLD TSLETLLIII
DSNNLQNFMP LLVKRLMVLS NTKVVENNRI VNTERIRYLS LKCLLELLRT NDKSTILLYK
PEMLVGLVTN LDDPRRSIRK LSCDIRQLLF EAREST
//
