ID G3B8F4_CANTC Unreviewed; 707 AA.
AC G3B8F4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 08-NOV-2023, entry version 51.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CANTEDRAFT_126248 {ECO:0000313|EMBL:EGV62386.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV62386.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
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DR EMBL; GL996527; EGV62386.1; -; Genomic_DNA.
DR RefSeq; XP_006688556.1; XM_006688493.1.
DR AlphaFoldDB; G3B8F4; -.
DR STRING; 590646.G3B8F4; -.
DR GeneID; 18249156; -.
DR KEGG; cten:CANTEDRAFT_126248; -.
DR eggNOG; KOG2327; Eukaryota.
DR HOGENOM; CLU_024202_0_0_1; -.
DR OrthoDB; 21093at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR PIRSF; PIRSF003033; Ku70; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000707};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 375..527
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 707 AA; 80946 MW; 351D34D1233ED399 CRC64;
MSSYAFEDDD EYGTDRQYAI RDGIIFLVEL NDEIFRPLKS LGGKSQILQI LWSINRLLQE
SVIMAPSTGV GVFFYNCSKS HSGFPKESRV DRLFRLHELN LKDMRRLNFL IEDELSGLKP
IRDSFSPSSD PVVDLNEVFN VVYEEFKTQS TKSFNRKKLI WFTNNHNPYN LTQLEGNEEL
LSKLRETTAN YFAEMIPIVP MFLKLDTNDT FDLKFFESVF SNTNFLTLKN KLFDSNNGDN
TVVVDKIGSI ISRIKQVRRI QIGCNLILSD GKIGGKFGCS VKGYTLYNHE QMKKVSHIYA
DAEDLTVVQS EATIKTKDDH EVVKIPDDPN TTYEERKSKA GGRKGFSLKY KNEDATMEDV
FYLDNKQVEF LKQYTFDHSP EDDTKVESES EDDLKHEDED VPYVALSHPP YLKLLGFRHV
SKFKPYYNMA APIFITFDSS NGYSLPLGFQ NSKDTFTNLY KSCVKLERYA MLFGCTKKNA
LPSLFALYPT NIAKSSNQDS LPEGFLLVRL PWLDDIRALP PHMIKNPLIQ FDKSKSSLPT
ALVDSFKVLM KKLHIQNYNP GDFPNPSLNF FYEVLKNDLL QIESSDAHMS IEKFDATFQY
LENISTILSK GDLKRVVESI NKDLDASGVL LIDEDPMEPP TKKPKPTVEV DDSDILTAWK
SNSLNQFNMN QLKSFVSRYK NSIKSATKKQ DLINNIVDFL ESRNAAT
//
