ID G3GRU9_CRIGR Unreviewed; 506 AA.
AC G3GRU9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Large neutral amino acids transporter small subunit 1 {ECO:0000313|EMBL:EGV94093.1, ECO:0000313|RefSeq:XP_027266497.1};
DE SubName: Full=Solute carrier family 7 member 5 {ECO:0000313|Ensembl:ENSCGRP00001022472.1};
GN Name=Slc7a5 {ECO:0000313|Ensembl:ENSCGRP00001022472.1,
GN ECO:0000313|RefSeq:XP_027266497.1};
GN ORFNames=I79_000243 {ECO:0000313|EMBL:EGV94093.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV94093.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV94093.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001022472.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027266497.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027266497.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027266497.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000256|ARBA:ARBA00007040}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000004; EGV94093.1; -; Genomic_DNA.
DR RefSeq; XP_003495149.1; XM_003495101.3.
DR RefSeq; XP_027266497.1; XM_027410696.2.
DR STRING; 10029.G3GRU9; -.
DR PaxDb; 10029-XP_007622168-1; -.
DR Ensembl; ENSCGRT00001026717.1; ENSCGRP00001022472.1; ENSCGRG00001021000.1.
DR GeneID; 100768667; -.
DR CTD; 8140; -.
DR eggNOG; KOG1287; Eukaryota.
DR GeneTree; ENSGT00940000155581; -.
DR OMA; WCQKVME; -.
DR OrthoDB; 1103451at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015804; P:neutral amino acid transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004760; L_AA_transporter.
DR NCBIfam; TIGR00911; 2A0308; 1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF315; LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 506 AA; 55206 MW; 975D44E05346E07F CRC64;
MAGPGAKRRA VAVPAAAEEE KQAREKMLEA RRADGADLGA EGVTLQRNIT LLNGVAIIVG
TIIGSGIFVT PTGVLKEAGS PGLALVVWAV CGVFSIVGAL CYAELGTTIS KSGGDYAYML
EVYGSLPAFL KLWIELLIIR PSSQYIVALV FATYLLKPIF PTCPVPEEAA KLVACLCVLL
LTAVNCYSVK AATRVQDAFA AAKLLALALI ILLGFIQMGK GDMSNLHPQS SFEGTNLDVG
NIVLALYSGL FAYGGWNYLN FVTEEMINPY RNLPLAIIIS LPIVTLVYVL TNLAYFTTLS
TNQMLMSEAV AVDFGNYHLG VMSWIIPVFV GLSCFGSVNG SLFTSSRLFF VGSREGHLPS
VLSMIHPQLL TPVPSLVFTC VMTLMYAFSN DIFSIINFFS FFNWLCVALA IIGMMWLRFK
KPELERPIKV NLALPVFFIL ACLFLIAVSF WKTPKECGIG FAIILSGLPV YFFGVWWQNK
PKWLLQAIFS VTVLCQKLMQ VVPQET
//
