ID G3GS04_CRIGR Unreviewed; 1015 AA.
AC G3GS04;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 1 {ECO:0000313|EMBL:EGV97704.1};
GN ORFNames=I79_000312 {ECO:0000313|EMBL:EGV97704.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97704.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; JH000005; EGV97704.1; -; Genomic_DNA.
DR AlphaFoldDB; G3GS04; -.
DR STRING; 10029.G3GS04; -.
DR PaxDb; 10029-XP_007636072-1; -.
DR eggNOG; KOG0931; Eukaryota.
DR InParanoid; G3GS04; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 511..704
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 113637 MW; A26BBFBCDBC40228 CRC64;
MRVSGNRKHS KTLLAAVPVE GEAPSSETGT SLDSPSAYHQ GPLVPGSSLS PDHYEHTSVS
AYGLYAGSGP QQRTRRPRLQ HSTSVLRKQA EEEAIKRSRS LSESYELSSD LQDKQVEMLE
RKYGGRLVTR HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE
KVHSSYFEGK QVSVTNDGSQ LGALVPSECG DLSDPALKSP APSSDFADAI TELEDAFSRQ
VKSLAESIDD ALNCRSLHSE EVPAPDTARA RDTEPKPGLH GMDHHKLDEM TASYSDVTLY
IDEEELSPPL PLSQAGDRPS STESDLRLRA GGTAQDYWAL AHKEDKADTD TSCRSTPSLE
RPEPRLRVEH LPLLTIEPPS DSSVELSDRS DRSSLKRQSA YERSLGGQQS SPKHGPHGGP
PKGIPREEPE LRPRPPRPLE SHLAINGSAN RQSKSESDYS DGDNDSINST SNSNDTINCS
SESSSRDSLR EQTLSKQTYH KETRNSWDSP AFSNDVIRKR HYRIGLNLFN KKPEKGIQYL
IERGFVPDTP VGVAHFLLQR KGLSRQMIGE FLGNRQKQFN RDVLDCVVDE MDFSAMELDE
ALRKFQAHIR VQGEAQKVER LIEAFSQRYC VCNPGVVRQF RNPDTIFILA FAIILLNTDM
YSPNVKPERK MKLEDFVKNL RGVDDGEDIP RETLIGIYER IRKRELKTNE DHVSQVQKVE
KLIVGKKPIG SLHHGLGCVL SLPHRRLVCY CRLFEVPDPN KPQKLGLHQR EIFLFNDLLV
VTKIFQKKKN SVTYSFRQSF SLYGMQVLLF ENQYYPNGIR LTSAVPGADI KVLINFNAPN
PQDRKKFTDD LRESVAEVQE MEKHRIESEL EKQKGVVRPS MSQCSSLKKE SGNGTLSRAC
LDDSYASSEG LKRSALSSSL RDLSEADTWA SPNCGQWQRQ AAVAAAGLVC VSNLWYCMFW
AGKRGRRSSA GSLESNVEAV YGSSHSAPEV CGPYLLASTA LVPPTHSFLE LCMAL
//
