ID G3GSN5_CRIGR Unreviewed; 559 AA.
AC G3GSN5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Solute carrier family 12 member 8 {ECO:0000313|EMBL:EGV96400.1};
GN ORFNames=I79_000652 {ECO:0000313|EMBL:EGV96400.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV96400.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; JH000012; EGV96400.1; -; Genomic_DNA.
DR AlphaFoldDB; G3GSN5; -.
DR STRING; 10029.G3GSN5; -.
DR PaxDb; 10029-XP_007624373-1; -.
DR eggNOG; KOG2083; Eukaryota.
DR InParanoid; G3GSN5; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF6; SOLUTE CARRIER FAMILY 12 MEMBER 8; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..387
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 519..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 59597 MW; AD33603F9892D925 CRC64;
MSLCSLQGIL AQPQPWWKIQ LFMWEPVLFG TWDGVFTSCM INIFGVVLFL RTGWLVGNTG
VLLGLLLVSF VILVALITVL SGIGVAEHGG IGSGGVYSMI SSVLGGQMGG TVGLLYVFGQ
CVAGAMYITG FAESISDLLG LGNIWAVRGI SVVVLLALLG INLAGVKWII RLQLLLLFLL
AVSTLDFVVG SFTHLDPEHG FIGYSPELLE SNTLPEYSPG ESFFTVFGVF FPAATGVMAG
FNMGGDLREP ATSIPLGSLA AVGISWFLYI IFTFLLGAIC TREALRSDFL IAEKVSLVGF
LFLLGLYISS LASCMGGLYG APRILQCIAQ EKVVPVLAFL GQGKGPNKTP VAAICLTSLV
TMAFVLVGQV NVLAPVVTIN FMLTYIAVDY SYFALSMAHS SLPQSPEPVP REGPGALRCS
EHLLQDKAPS YGSDTPAGSL SEGTLLEFTK DMDQLLQPTG RIESHQLGSI KGNRIPKRQK
GKCKKVAKRT LQDSFLLDSG SPSFFPTEAS GGLPAAFWEG QESCQNQQAS RSESHDQLVP
DLCTQPRGNG EEASVDPSP
//
