ID G3GYM1_CRIGR Unreviewed; 1077 AA.
AC G3GYM1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=I79_002901 {ECO:0000313|EMBL:EGW03961.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03961.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000067; EGW03961.1; -; Genomic_DNA.
DR AlphaFoldDB; G3GYM1; -.
DR STRING; 10029.G3GYM1; -.
DR PaxDb; 10029-XP_007619633-1; -.
DR eggNOG; KOG0791; Eukaryota.
DR InParanoid; G3GYM1; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd14615; R-PTPc-J; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 7.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:EGW03961.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 705..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 186..270
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 271..357
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 450..546
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 767..1038
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 956..1029
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1077 AA; 120007 MW; 8C35A10A5621B497 CRC64;
MNTNDIERSP VANLSQVHRN FLCSVVLACV QSPSLTQVLL TGLKPGTNYT AKVYPRAADD
TEGQPGIKAF TTDPIKVSDI RAVSISATNM TLTWKINNNE SSFCYTYKIH VAGGSSAFNQ
TVNKTEAIIR GLTSSGSSAS NQTVNKTEAI IRGLTSSTLY NITICPFLGH DEGESDFLQV
YTSPGPVSDF QVTNVNIREI GLTWRSNDSE FRILTMEVGG EKIKNYTTRN QSFIIEDLKP
GTSYHFEIFP RGPDGTEGPS RTVDGRTDRS AVIDIRIVSV TSSEMQLEWE NTDSTSGYNY
HVVLESECGR SNTTSSQKSI TLRDLTPGTL YNVTVTPEVE QVQGDATSVA QYTRPSNVSD
IEVNTSTTVA TIWWNNLDKA SPKYSYRLIL KAGDGSNVTK MIITDVGITS QMVYDLIPGS
SYTVEIFAKV GNVTESLVPG WKSFCMEPAP VAFFHCEVVP KEPVLVLKWP CPPGMNTGFE
LGVRNDTWNN MTYLKNCNSE DDTECRGKVQ NLTFSTSYNI SIVTLSCGKM AAPTQSTCTT
GITDPPSPDG SPNITSVSHN SVKVKFSGFK ASNGPIKAYA IILTTGEAGQ PSADVLKYTY
EDFKKGASDT YVTYLIRIEE KGRSPGLSEV LKYEIDVGNQ STTLGYYNGR LEPLGSYRVC
VAGFTNIAYN LHNEQLINGN ESYVSFSQYS EAVFLPQDPG VICGAVFGCI FGALAIVAVG
GFVFWRKKRK DAKNNEVSFS QIKSKLIRVE NFEAYFKKQQ ADSNCGFAEE YEARGRKLFC
IMGKLWDLKL IGISLPKYTA EVAENRGKNR YNNVLPYDIS RVKLSVQTHS TDDYINANYM
PGYHSKKDFI ATQGPLPNTL KDFWRMVWEK NVYAIVMLTK CVEQGRTKCE EYWPSKQAHD
YGDITVAMTS EVVLPEWTIR DFVVKNMQTS ESHPLRQFHF TSWPDHGVPD TTDLLINFRY
LVRDYMKQIP PESPILVHCS AGVGRTGTFI AIDRLIYQIE NENTVDVYGI VYDLRMHRPL
MVQTEDQYVF LNQCVLDIIR AQKDSKVDLI YQNTTAMTIY ENLEPVSMFG KTNGYIA
//