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Database: UniProt
Entry: G3GZ29_CRIGR
LinkDB: G3GZ29_CRIGR
Original site: G3GZ29_CRIGR 
ID   G3GZ29_CRIGR            Unreviewed;       724 AA.
AC   G3GZ29;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   10-OCT-2018, entry version 33.
DE   SubName: Full=Coagulation factor XIII A chain {ECO:0000313|EMBL:EGV98233.1};
GN   ORFNames=I79_003080 {ECO:0000313|EMBL:EGV98233.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98233.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; JH000071; EGV98233.1; -; Genomic_DNA.
DR   PRIDE; G3GZ29; -.
DR   InParanoid; G3GZ29; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR034810; Factor_XIII_A.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590:SF42; PTHR11590:SF42; 1.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN      307    392       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    315    315       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    366    366       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    389    389       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       429    429       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       431    431       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       478    478       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       483    483       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   724 AA;  82135 MW;  EFDDDA7ED32EBC0E CRC64;
     MSDTPATTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLQDYLKVTA VHLFKERWDS
     NKVDHHTDKY DNSKLIVRRG QTFYVQIDFN RPYNPERDLF RVEYVIGRYP QENKGTYIPV
     PVVSELQSGK WGAKVIMNED RSVRLTIQSS PKCIVGKFRM YVAVWTPYGI LRTRRDPETD
     TYILFNPWCE EDAVYLDDER EREEYVLNDI GVIFYGDFSD IKSRSWSYGQ FEDGILDACL
     YVMDKAQMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL
     LEYRSSETPV RYGQCWVFAG VFNTSRVVTN YFSAHDNDAN LQMDVFLEED GSVSSKLTKD
     SVWNYHCWNE AWMTRPDLPV GFGGWQAVDS TPQENSDGMY RCGPASVQAV KHGHVCFQFD
     APFVFAEVNS DLVYITAKKN GTHVVESVDT THIGKLIVTK QIGGDGMQDI TDTYKFQEGQ
     EEERLALETA LMYGAKKALN TEGVVKPKND VDMDFEVENA VLGKDFKVTI TFHNNSTNLY
     NVSAYLSGNI TFYTGVSKEE FKNEAFEISL EPFSFKKKEV LVRAGEYMSH LLEQGLLHFF
     VTARINETRD ILAKQKSTVL TIPKVTIKVR GTAMVGSDMV VTVEFTNPLK ETLQNVWFHL
     DGPGVTLPKR KMFREIHPNA TVQWEEVCRP WVSGPRKLIA SMTSDTLRHV YGELDLQIQR
     RPSM
//
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