ID G3GZH0_CRIGR Unreviewed; 542 AA.
AC G3GZH0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Kinesin light chain {ECO:0000256|RuleBase:RU367020};
GN ORFNames=I79_003230 {ECO:0000313|EMBL:EGW05645.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW05645.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: Kinesin is a microtubule-associated force-producing protein
CC that play a role in organelle transport.
CC {ECO:0000256|RuleBase:RU367020}.
CC -!- SUBUNIT: Oligomeric complex composed of two heavy chains and two light
CC chains. {ECO:0000256|RuleBase:RU367020}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|RuleBase:RU367020}.
CC -!- SIMILARITY: Belongs to the kinesin light chain family.
CC {ECO:0000256|RuleBase:RU367020}.
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DR EMBL; JH000078; EGW05645.1; -; Genomic_DNA.
DR AlphaFoldDB; G3GZH0; -.
DR STRING; 10029.G3GZH0; -.
DR PaxDb; 10029-XP_007637870-1; -.
DR eggNOG; KOG1840; Eukaryota.
DR InParanoid; G3GZH0; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR002151; Kinesin_light.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13424; TPR_12; 3.
DR Pfam; PF13176; TPR_7; 1.
DR PRINTS; PR00381; KINESINLIGHT.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU367020};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367020};
KW Microtubule {ECO:0000256|RuleBase:RU367020};
KW Motor protein {ECO:0000256|RuleBase:RU367020};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 197..230
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 305..338
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 347..380
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 389..422
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 431..464
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 473..506
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 346..373
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 542 AA; 62466 MW; E734FDD92C692EDD CRC64;
MELYPEMSWA SMTSIVHSLH KMCLLTYSCG LLRFRHLQAW ETVKLEYMED PTLISSYRQK
LINYFTSQLS QDRVTWRSAD ELPWLFQQQG SKQKLHDCLL NLLVSQNLYK RGHFAELLSY
WQFVGKDKGA MATEYFESLK QYGNYEGEEN MLCLADLYET LGRFLKDLGL LSQAVVPLQR
SLEIRETALD PDHPRVAQSL HQLASVYVQW KKFADAEQLY KQALEISENA YGADHPQAAR
ELEALATLYH KQNKYEQAEH FRKKSVIIRQ QATRRKGSLY GFALLRRRAL QLEELTLGKD
KPENARTLNE LGVLYYLQNN LETAEQFLKR SLEMRERVLG PDHPDCAQSL NNLAALCNEK
KQYEKAEELY ERALDIRRRA LAPDHPSLAY TVKHLAILYK KTGRVDKAVP LYELAVEIRQ
KSFGPKHPSV ATALVNLAVL HSQMKKHSEA LPLYERALKI YEDSLGRMHP RVGETLKNLA
VLSYEEGNFE KAAELYKRAM EIKEAETSLL GGKAPSRQSS SGDTFIFKTT HSPNIFLPQG
QR
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