ID G3GZJ7_CRIGR Unreviewed; 699 AA.
AC G3GZJ7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=EEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSCGRP00001013214.1, ECO:0000313|RefSeq:XP_027273019.1};
DE SubName: Full=Methyltransferase-like protein 13 {ECO:0000313|EMBL:EGV93277.1};
GN Name=Eef1aknmt {ECO:0000313|Ensembl:ENSCGRP00001013214.1,
GN ECO:0000313|RefSeq:XP_027273019.1};
GN ORFNames=I79_003269 {ECO:0000313|EMBL:EGV93277.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93277.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV93277.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001013214.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027273019.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027273019.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027273019.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000079; EGV93277.1; -; Genomic_DNA.
DR RefSeq; XP_003497701.1; XM_003497653.3.
DR RefSeq; XP_007628138.1; XM_007629948.2.
DR RefSeq; XP_027273019.1; XM_027417218.2.
DR STRING; 10029.G3GZJ7; -.
DR PaxDb; 10029-XP_007628138-1; -.
DR Ensembl; ENSCGRT00001017451.1; ENSCGRP00001013214.1; ENSCGRG00001014417.1.
DR GeneID; 100771851; -.
DR KEGG; cge:100771851; -.
DR CTD; 51603; -.
DR eggNOG; KOG2352; Eukaryota.
DR GeneTree; ENSGT00510000047399; -.
DR OMA; REIEWLF; -.
DR OrthoDB; 179741at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR12176:SF88; SPERMINE_SPERMIDINE SYNTHASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G08500); 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EGV93277.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EGV93277.1}.
FT DOMAIN 52..147
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT REGION 433..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 79150 MW; 77FA177B8EAD8E5B CRC64;
MNLLPKSSKE FGSVDYWEKF FQQRGKRSFE WYGTYLELCE VLHKYIKPRE KVLVIGCGNS
ELSEQLYDVG YEDIVNIDIS EVVIKQMKER NAGRRPRMSF MKMDMTQMDF PDATFQVVLD
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
VRVHQVANSQ DQVFEAEPRF SLPVFAFVMT KFRPVPGSAL HIFELCTQEQ GKPVRLESAD
RLAEAVRERQ HYAWLCSQLR RKAGLGSISL DLCSGDTGEP RYTLHVVDNP TVKPSRDSHF
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLVTVALHR GQQYDGMESI QAELSTRVME
LAPAGMPPQQ QVPFLSVGGD IGVRTVQHQD HSALSGDYVI EDVQGEDRWY FRRLIFLSNR
NVVQSEARLL KDVSHRAQKK RKKDRKKHRP ADTPEDFPSA PGQSIDKSYL CCEHHKAMIA
GLALLRNPEQ LLETPLTLLV VGLGGGSLPL FVHDHFPESR VDAVEIDPSM LEVATQWFGF
SQSDRMKVHI ADGLDYITSL AGGEARPHYD VIMFDVDSKD PTLGMSCPPP AFVDQLFLQK
VKSILSHEGI FILNLVCRDL ELKDSVLAGL KAAFPLLYVR RIEGEVNEIL FCQLQPEQKL
ATPELLEMAQ ALERTLRKPG QGWDDTYVLS DMLKTVTIV
//
