ID G3GZP0_CRIGR Unreviewed; 331 AA.
AC G3GZP0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Quinone oxidoreductase PIG3 {ECO:0000313|EMBL:EGV91877.1, ECO:0000313|RefSeq:XP_027280383.1};
DE SubName: Full=Quinone oxidoreductase PIG3-like protein {ECO:0000313|EMBL:ERE68001.1};
DE EC=1.-.-.- {ECO:0000313|EMBL:ERE68001.1};
DE SubName: Full=Tumor protein p53 inducible protein 3 {ECO:0000313|Ensembl:ENSCGRP00001009670.1};
GN Name=Tp53i3 {ECO:0000313|Ensembl:ENSCGRP00001009670.1,
GN ECO:0000313|RefSeq:XP_027280383.1};
GN ORFNames=H671_7g18262 {ECO:0000313|EMBL:ERE68001.1}, I79_003332
GN {ECO:0000313|EMBL:EGV91877.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV91877.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV91877.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000030759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX PubMed=23929341; DOI=10.1038/nbt.2645;
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puhler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Nat. Biotechnol. 31:694-695(2013).
RN [4] {ECO:0000313|EMBL:ERE68001.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE68001.1};
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puehler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCGRP00001009670.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:XP_027280383.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027280383.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027280383.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000081; EGV91877.1; -; Genomic_DNA.
DR EMBL; KE682078; ERE68001.1; -; Genomic_DNA.
DR RefSeq; XP_003497742.1; XM_003497694.3.
DR RefSeq; XP_007636589.1; XM_007638399.2.
DR RefSeq; XP_027280383.1; XM_027424582.2.
DR STRING; 10029.G3GZP0; -.
DR PaxDb; 10029-XP_007636589-1; -.
DR Ensembl; ENSCGRT00001013889.1; ENSCGRP00001009670.1; ENSCGRG00001011738.1.
DR GeneID; 100760375; -.
DR KEGG; cge:100760375; -.
DR CTD; 9540; -.
DR eggNOG; KOG1198; Eukaryota.
DR GeneTree; ENSGT00940000161217; -.
DR OMA; WAEVPDP; -.
DR OrthoDB; 2598390at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000030759; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0070402; F:NADPH binding; IEA:Ensembl.
DR GO; GO:0003960; F:NADPH:quinone reductase activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0048038; F:quinone binding; IEA:Ensembl.
DR GO; GO:0006739; P:NADP metabolic process; IEA:Ensembl.
DR CDD; cd05276; p53_inducible_oxidoreductase; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR014189; Quinone_OxRdtase_PIG3.
DR NCBIfam; TIGR02824; quinone_pig3; 1.
DR PANTHER; PTHR48106:SF8; QUINONE OXIDOREDUCTASE PIG3; 1.
DR PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ERE68001.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 10..327
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 331 AA; 35367 MW; 11B76EDCEBFA691A CRC64;
MLAVHFDQPG GPENLYLKEV AKPSPGEGEV LLKVAASALN RADLLQRLGQ YAPPPGASSI
LGLEASGHVA ELGPGCQGHW KIGDLAMALL PGGGQAQYVS VPEDLLMPIP EGLTLSQAAA
IPEAWITAFQ LLHLVGNVQV GDYVLIHAGS SGVGTAAIQL ARKAGAIPLV TAGSQHKLQM
AEKLGAAAGF NYREDFSEST LRFTNGVGVD LILDCIGGSY WEKNVNCLAL DGRWVLYGLI
GGADVSGPLF SKLLFKRGSL ITSLLRSRDN KYKQTLVKTF TEQILPYFSK DSPQRLLPVL
DRVYQATDIQ AAHEYMEANK NVGKIVLELP Q
//
