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Database: UniProt
Entry: G3H0G9_CRIGR
LinkDB: G3H0G9_CRIGR
Original site: G3H0G9_CRIGR 
ID   G3H0G9_CRIGR            Unreviewed;       202 AA.
AC   G3H0G9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=Endothelin-1 {ECO:0000256|ARBA:ARBA00040197};
GN   Name=Edn1 {ECO:0000313|Ensembl:ENSCGRP00001000457.1,
GN   ECO:0000313|RefSeq:XP_027266225.1};
GN   ORFNames=I79_003625 {ECO:0000313|EMBL:EGV92890.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV92890.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
RN   [2] {ECO:0000313|EMBL:EGV92890.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSCGRP00001000457.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [4] {ECO:0000313|RefSeq:XP_027266225.1}
RP   IDENTIFICATION.
RC   STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027266225.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_027266225.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000256|ARBA:ARBA00010959}.
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DR   EMBL; JH000091; EGV92890.1; -; Genomic_DNA.
DR   RefSeq; XP_003497989.1; XM_003497941.3.
DR   RefSeq; XP_007630581.1; XM_007632391.1.
DR   RefSeq; XP_027266225.1; XM_027410424.2.
DR   STRING; 10029.G3H0G9; -.
DR   PaxDb; 10029-XP_007630581-1; -.
DR   Ensembl; ENSCGRT00001000481.1; ENSCGRP00001000457.1; ENSCGRG00001000376.1.
DR   GeneID; 100768493; -.
DR   KEGG; cge:100768493; -.
DR   CTD; 1906; -.
DR   eggNOG; ENOG502S1NV; Eukaryota.
DR   GeneTree; ENSGT00950000183053; -.
DR   OMA; CIHQQLV; -.
DR   OrthoDB; 4265288at2759; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   Proteomes; UP000694386; Unplaced.
DR   Proteomes; UP001108280; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
DR   GO; GO:0031707; F:endothelin A receptor binding; IEA:Ensembl.
DR   GO; GO:0031708; F:endothelin B receptor binding; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR   GO; GO:0060385; P:axonogenesis involved in innervation; IEA:Ensembl.
DR   GO; GO:0007589; P:body fluid secretion; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
DR   GO; GO:0044751; P:cellular response to human chorionic gonadotropin stimulus; IEA:Ensembl.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR   GO; GO:0086101; P:endothelin receptor signaling pathway involved in heart process; IEA:Ensembl.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0072011; P:glomerular endothelium development; IEA:Ensembl.
DR   GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl.
DR   GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR   GO; GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051248; P:negative regulation of protein metabolic process; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0014034; P:neural crest cell fate commitment; IEA:Ensembl.
DR   GO; GO:0030185; P:nitric oxide transport; IEA:Ensembl.
DR   GO; GO:0003357; P:noradrenergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0030072; P:peptide hormone secretion; IEA:Ensembl.
DR   GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR   GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0031583; P:phospholipase D-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0072112; P:podocyte differentiation; IEA:Ensembl.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:Ensembl.
DR   GO; GO:0070101; P:positive regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0046887; P:positive regulation of hormone secretion; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
DR   GO; GO:0060298; P:positive regulation of sarcomere organization; IEA:Ensembl.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0035810; P:positive regulation of urine volume; IEA:Ensembl.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR   GO; GO:0042313; P:protein kinase C deactivation; IEA:Ensembl.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Ensembl.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR   GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0043179; P:rhythmic excitation; IEA:Ensembl.
DR   GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl.
DR   GO; GO:0097492; P:sympathetic neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; ENDOTHELIN; 1.
DR   PANTHER; PTHR13874:SF10; ENDOTHELIN-1; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW   Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..202
FT                   /note="Endothelin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040662421"
FT   DOMAIN          52..73
FT                   /note="Endothelin-like toxin"
FT                   /evidence="ECO:0000259|SMART:SM00272"
FT   DOMAIN          109..130
FT                   /note="Endothelin-like toxin"
FT                   /evidence="ECO:0000259|SMART:SM00272"
SQ   SEQUENCE   202 AA;  23108 MW;  485654EF3A15BD07 CRC64;
     MDYFPVIFSL LFVAFQGAPE TAVLGAELST RAENGGYSPT PSTSWRPRRS KRCSCSSLMD
     KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLS PKTTDHGNRC QCAQQKDRKC
     WNFCQGGKEL RAQNTMQKGL EDFKKRKACS KLGKKCINQQ LVEERKIRRL EAITNSIKTS
     FRVAKLKADL YRDQKLTHNR AH
//
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