ID G3H0I5_CRIGR Unreviewed; 1082 AA.
AC G3H0I5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN ORFNames=I79_003643 {ECO:0000313|EMBL:EGV96446.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV96446.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; JH000092; EGV96446.1; -; Genomic_DNA.
DR AlphaFoldDB; G3H0I5; -.
DR STRING; 10029.G3H0I5; -.
DR PaxDb; 10029-XP_007625639-1; -.
DR eggNOG; KOG2200; Eukaryota.
DR InParanoid; G3H0I5; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 632..838
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 868..1053
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 113..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 122347 MW; FDA84E921044A52E CRC64;
MILTQIEAKE ACDWLRVTGF PQYAQLYEDL LFPIDISLVK REHDFLDRDA IEALCRRLNT
LNKCAVMKLE VSPHRKRSED SDEDEPCAIS GKWTFQRDSK RWSRLEEFDV FSPKHDPIPG
SPDDPHLQSA TSHESMLTDL SERQEVSSVR SLSSTSSVPT HVPHSGDAVT PRTNSVISVC
SSSHFVGNDD SFSSLPSPKE LSSFSFSMKG HEKNTKSKTR SLLKRMESLK LKGSHHSKHK
APSKLGLIIS APILQEGMDE EKLKQLNCVE ISALNGNHIN VPMVRKRSVS NSTQTSSSSS
QSETSSAVST PSPVTRTRSL STCNKRVGMY LEGFDPFSQS TLNSVTEQNY KNRESYPEDT
VFYIPEDHKP GTFPKALSNG SFCSSGSSSV NWRTGSFHGP GHLSLRRENS SDSPKELKRR
NSSSSVSSRL SIYDNVPGSI LYSSSGDLAD LENEDIFPEL DDILYHVKGM QRIVNQWSEK
FSDEGDSDSA LDSVSPCPSS PKQIHLDVEH DRRTPSDLDS TGNSLNEPEE PTDIPERRDS
GVGASLTRCK RHRLRWHSFQ SSHRPSLNSV SLQINCQSVV QMNLLQKYSL LKLTALLEKY
TPSNKHGFSW AVPKFMKRIK VPDYKDRSVF GVPLTVNVQR SGQPLPQSIQ QAMRYLRNHC
LDQVGLFRKS GVKSRIQALR QMNEGAEDYV NYEGQSAYDV ADMLKQYFRD LPEPLMTNKL
SETFLQIYQY VPKDQRLQAI KAAIMLLPDE NREVLQTLLY FLSDVTAAVK ENQMTPTNLA
VCLAPSLFHL NTLKRENSSP RVMQRKQSLG KPDQRDLNEN LAATQGLAHM IAECKKLFQV
PEEMSRCRNS YTEQELKPLT LEALGHLSSD QPADYRHFLQ DCVDGLFKEV KEKFKGWVSY
PTSEQAELSY KKVSEGPPLR LWRSTIEVPA TPEEILKRLL KEQHLWDMDL LDSKVIETLD
SQTEVYQYVQ NSMAPHPARD YVVLRTWRTN LPRGACALLL TSVDHDRAPV VGVRVNVLLS
RYLMEPCGSG KSKLTYMCRA DLRGHMPEWY TKSFGHLCAA EVVKIRDSFS NQNTETKDNK
SR
//
