ID G3H0Z4_CRIGR Unreviewed; 4009 AA.
AC G3H0Z4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=MAX gene-associated protein {ECO:0000313|EMBL:EGV97255.1};
GN ORFNames=I79_003815 {ECO:0000313|EMBL:EGV97255.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97255.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR EMBL; JH000098; EGV97255.1; -; Genomic_DNA.
DR STRING; 10029.G3H0Z4; -.
DR PaxDb; 10029-XP_007610675-1; -.
DR eggNOG; KOG3585; Eukaryota.
DR InParanoid; G3H0Z4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18911; bHLHzip_MGA; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037935; MAX_gene-associated_bHLHzip.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR018186; TF_T-box_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44813; MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR44813:SF1; MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00425; TBOX; 1.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00201};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00201};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 79..260
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 2151..2202
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REPEAT 3389..3430
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 259..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2422..2442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2662..2683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3438..3666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3798..3891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1809
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2422..2439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3443..3458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3504..3524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3537..3552
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3598..3641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3807..3832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3874..3888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4009 AA; 437556 MW; 7821F13F17C031D6 CRC64;
MEEKQQIILA NQDGGTVTGA APTFFVILKQ PGNGKTDQGI LVTNRDACAL SNRVSSPGKS
KGKICLPADC TVGRITVTLD NNSMWNEFHN RSTEMILTKQ GRRMFPYCRY WITGLDSNLK
YILVMDISPV DNHRYKWNGR WWEPSGKAEP HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK
LTNNTLDQEG HIILHSMHRY LPRLHLVPAE KATEVIQLNG PGVHTFTFPQ TEFFAVTAYQ
NIQITQLKID YNPFAKGFRD DGLSSKPQRD GKQRNSSDQE GNSVSSSPGH RVRLTEGEGS
EIHPGDLVLR GHETSGLGLE KPPRNVKQDF LGFMSTDSTL EVPQLKHEIS ESLISNSFED
GSQIVSPLNP NGNFNVVIKE EPLDDYDYEL GECPEGVTVK QEETDEETDV YSNSDDDPIL
EKQLKRHKKV DNWETDHQSY KWLPSSPGVA KAKMFKLDAG KMPVVYLEPC AVTKSTVKIS
ELPDNMLSRK DKSVLEELEY LPAYIENSGG TDICLNKDSE NSLRKQSSDI RMAQKYTLLK
EPQWKYPDIF DNSSTERIND SSKASTGDSF SGKEDLGRKR TTILKMTTPS KTVNASQSAS
PNTPGKRGRP RKLRLSKAGR PPKNTGKPLT STKNIPVGPG NTFPDVKPDL EDVDGVLFVS
FESKEALDIH AVDGTTEEPS SLPTTTTNDS GCRTRISQLE KELIEDLKSL RHKQVIHPAL
QEVGLKLNSV DPTMSIDLKY LGVQLPLAPA TSLPFWNLTG TNPASPDAGF PFVSRTGKTN
DFTKIKGWRG KFHSASASRN EGGNAEASLK NRSAFCSDKL DEYLENEGKL METSMGFSSN
APTSPVVYQL PTKSTSYVRT LDSVLKKQST VSPSTSYSVK SHSITTASRK TKSQNKQTTL
SGRTKSSYKS ILPYSVSPKQ KNSPVTPGDK ITKNSLSTTS DNQATNFVVP TVDESAFPKQ
ISLRQAQQQQ LQQQQGTRPP GLSKSQVKLM DLEDCALWEG RPRTYITEER ADVSLTTLLT
AQKSPGGPTK LIEIISDCNW EEDRNKILSI LSQHINSNMP QSLKVGSFII ELASQRKCRG
EKNPPVYSSR VKISMPSTQG QDDMAEKSGS ETPDGPLSPG KMDDISPMQT DALDSVRERL
HGGKGLPFYA GLSPAGKLVA YKRKPSSTTS GLIQVNGKSY PQAKLLLGQM GALHPANRLA
AYITGRLRPS VLDLSTLSTV ISKVASNAKV AASRKPRTLL PSTSNSKMAS SGPTTNRSGK
NPKAFVPAKR PIAARPSPGG VFTQFVMSKV GALQQKIPGV RTPQPLTGPQ KFSIRPSPVM
VVTPVVSSEP VQVCSTVTAA VTSSPQVFLE NATAVTSMSA ISDVGAKEAT YSSGASDAGV
VEIAETNNTT PITSTQSTAT VNLIKTTGTS TSPVASVAFP KSLVASPTIS LPVASTASTS
IVVVTTAASS SVVTTPTSSL SSVPIILSGI NGSPPVSQRP PENSTQNPVT TPQMSPNSVK
RTGPRLLLIP VQQGSPTLRP IPNPQLQGQR MVLQPVRSPS GMNLFRHPSG QIVQLLPLHQ
IRGSNTQPSL QPVVFRNPGS VVGIRLPAPS KSSETPSSSA SSSAFSVMSP VIQAVGSSPT
VNVITQAPSL LSSGSSFVSQ AGTLTLRISP PEPQNFASKT GSESKITPST GGQPVGTASL
IPLQSGSFAL LQLPGQKSVP SSILQHVASL QVKKESQNAD QKVEINSIKR EEETKKALIS
KEEAVDTETD IIKQNSGIIV SEDTLNDSLD DGGDLLDEED VRPYEHSCST GSHTDEDKDG
DEESGNRSQN SPKEKQTVPE VRAVSEKVNS MTVQHVSKVR PQKCAEVKME QQQGSDNPED
PDEFLFISKE ESKFELSGSQ VKEQQSNSQA EVKKDCQSSL GKDNLRERWR KHLKGSSTQK
YIGISQDHKK EANMQFFTET KPCQENSEQD ISDLLGKSGA TESDGILKTE DSSWSSISSS
AAFSIIPRRA TKGRRGSRCF QGHVLLPREQ IKPKQETTGG RSSADFTVVD LEEEDEEDEK
TDDSFDEIVD VVSGYQSEEV DIEKNNYVDY IEDDEQVDVE TIEELSEEIN IAYKKTTATH
TQSFKQQCHS HISADEKASE KSRKVPLISP KLKDDFWSDD KLQKETEAFA YYRRTHTANE
RRRRGEMRDL FEKLKITLGL LHSSKVSKSL ILTRAFSEIQ GLTDQADKLI GQKNLLSRKR
SILIRKVSSL SGKTEEVVLK KLEYIYAKQQ ALEAQKRKKK MGSSEFGVSP RISKQLEGSA
TSSVDLRQMF ANNRRGKPLI LSRKRDQATE NALPSNTPHS SANLVMTPQG QLLTLKGPLF
SGPVVAVSPA LLDADLKPQG ASSTMAQSEN DDLFMMPRIV NVTSLAAEED LVDVGGSKYS
REVPDGKPLD HLRDIVGNEA SSLEDTDRIS SRGNHRDGRM TRGPTQVFLA NKDSGFPHVV
DVSNMQTSQE FVPKKISGDM RGHRYKWKES ELRGERLKSK ESQFHKLKVK DLKDSSLEME
LRKVASAIEE AALDPSELLT NTEDEDDTDE TLTSLLNEIA FLNQQLNDDS ELPGSMDTEF
PEDAQRAFIS KLAPGNRSTF QVGHLGTSLK ELPDVQEENE SISPLLLHLE DDDFSENEKQ
LGDTASEPDV LKIVIDSEIK DSHVPHRKSS DGGKSTSGLP AEPESGLLVM MAGEGSTITS
RIKNLLRSPS IKLRRSKTGN RREDLSSKVT LEKVLGVTVS GGSGLACDPR SGLVAYPAGC
VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKFLVTGES GHMPAVRVWD VTERSQVAEL
QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV TAVSFSEDCS
YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG RGKKADSTFC
ITSSGLLCEF SDRRLLDKWV ELRNTDSFTT TVAHCISVSQ EYIFCGCADG TVRLFNPSNL
HFLSTLPRPH ALGTDIASIT EASRLFSGGA NARYPDTIAL TFDPTNQWLS CVYNDHSIYV
WDVRDPKKVG KVYSALYHSS CVWSVEVYPE VKDSNQACLP PSSFITCSSD NTIRLWNTES
SGVHGSTLHR NILSNDLIKI IYVDGNTQAL LDTELPGGDK ADGSLMDPRV GIRSVCISPN
GQHLASGDRM GTLRVHELQS LSEMLKVEAH DSEILCLEYS KPDTGLKLLA SASRDRLIHV
LDAGREYSLQ QTLDEHSSSI TAVKFAASDG QVRMISCGAD KSIYFRTAQK SGEGVQFTRT
HHVVRKTTLY DMDVEPSWKY TAIGCQDRNI RIFNISSGKQ KKLFKGSQGE DGTLIKVQTD
PSGIYIATSC SDKNLSIFDF SSGECVATMF GHSEIVTGMK FSNDCKHLIS VSGDSCIFVW
RLSSEMTISM RQRLAELRQR QRGGKQQGPT SPQRASGPKQ HQAPVVPPSG PALSSDSDKE
GEDEGTEEEE LPALPILGKS TKKEPDYSSS RLSSPEHPNE DSESTEPLSV DGISSDLEEP
AEGDEEEEEE GGTGLCGLQG GSPHTPDQEQ FLKQHFETLA NGAAPGGPAR VLERTESRSI
SSRFLLQVQT SPLRESSLSS SSLALMSRPD QVSQISGDQL KGNGATPPGA PPEMEPSSGN
SGPQQVAPVL LPRRRSNLDN SWAPKKMATT CPLAQLQKAQ SVHSLVPQDE VPSSRPLLFR
EVEIQGSLGS LPQADSCLSQ THSYQNPTTT NTAKLARSIS VGENPGLATE PQAPAPVRIS
PLNKLALPSR AHLVLDIPKP LPDRPTLTTF SPVTKGRVHN EAEQSGSLVS LGKAHTTFER
RAYSGEGATP KPRTEGQGDP GPNHPCALPV SNLLQGPESF QPPSPEKTAN PMECTRPGAA
LSQDSELALS LQQCEQLVAE LQGNVRQAVQ LYHLVTSCKT PSAEHSHITR LLRDTFSSVR
QELEALTGAV LSSPGGSPGA VGAEQTQALL EQYSELLLRA VERRMERRL
//