ID G3H2M9_CRIGR Unreviewed; 1359 AA.
AC G3H2M9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Plexin-A2 {ECO:0000313|EMBL:EGW02626.1};
GN ORFNames=I79_004446 {ECO:0000313|EMBL:EGW02626.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW02626.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000117; EGW02626.1; -; Genomic_DNA.
DR STRING; 10029.G3H2M9; -.
DR PaxDb; 10029-XP_007635156-1; -.
DR eggNOG; KOG3610; Eukaryota.
DR InParanoid; G3H2M9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 703..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..167
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 268..321
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 322..417
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 418..503
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 505..605
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 607..702
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT COILED 729..756
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1359 AA; 151973 MW; 67D2CC9A644FD4C0 CRC64;
MCSRRDKCQR AWEANRFAAS ISQCMSLEVH PSSISVSDHS RLLSLVVNDA PNLSEGIACA
FGNLTEVEGQ VSGSQVICIS PGPKDVPVIP VDQDWFGLEL QLRSKETGKI FVSTEFKFYN
CSAHQLCLSC VNSAFRCHWC KYRNLCTHDP TTCSFQEGRI NVSEDCPQLV PTEEILIPVG
EVKPITLKAR NLPQPQSGQR GYECVLNIQG AVHRVPALRF NSSSVQCQNS SYQYDGMDIS
NLAVDFAVVW NGNFIIDNPQ DLKVHLYKCA AQRESCGLCL KADHKFECGW CSDEHRCTLH
QHCPSTSSPW LDWSSHNVKC SNPQITEILT VSGPPEGGTR VTIHGVNLGL DFSEIAHHVQ
VAGVPCTPLP GEYIIAEQIV CEMGHAPTGT TSGPVRLCIG ECNEEFMTNS HQQYTFVNPS
VLSLSPIRGP ESGGTMVTIT GHYLGSGSSV AVYLGNQTCE FYGRSMNEIV CVSPPSSNGL
GPVPVSVSVD RARIDSSLQF EYIDDPRVQR IEPEWSITSG HTPLTITGFN LDVIQEPRIR
VKFNGKESVN VCTVVNTTTL TCLAPSLTSD YRPGLDTVER PDEFGFLFNN VQSLLIYNDT
KFIYYPNPTF ELLSPTGILD QKPGSPIILK GKNLCPPASG GAKLNYTVMI GETPCAVTVS
ETQLLCEPPN LTGQHKVMVH VGGMVFSPGS VSVISDSLLT LPAIISIAAG GSLLLIIVII
VLIAYKRKSR ENDLTLKRLQ MQMDNLESRV ALECKEAFAE LQTDINELTS DLDRSGIPYL
DYRTYAMRVL FPGIEDHPVL RELEVQGNGQ QHVEKALKLF AQLINNKVFL LTFIRTLELQ
RSFSMRDRGN VASLIMTGLQ GRLEYATDVL KQLLSDLIDK NLENKNHPKL LLRRTESVAE
KMLTNWFAFL LHKFLKECAG EPLFMLYCAI KQQMEKGPID AITGEARYSL SEDKLIRQQI
EYKTLILNCV NPDNENSPEI PVKVLNCDTI TQVKEKILDA VYKNVPYSQR PRAVDMDLEW
RQGRIARVVL QDEDITTKIE GDWKRLNTLM HYQVSDRSVV ALVPKQTSSY NIPASASISR
TSISRYDSSF RYTGSPDSLR SRVPMITPDL ESGVKVWHLV KNHDHGDQKE GDRGSKMVSE
IYLTRLLATK GTLQKFVDDL FETLFSTVHR GSALPLAIKY MFDFLDEQAD RHSIHDTDVR
HTWKSNCLPL RFWVNVIKNP QFVFDIHKGS ITDACLSVVA QTFMDSCSTS EHRLGKDSPS
NKLLYAKDIP SYKNWVERYY ADIAKLPAIS DQDMNAYLAE QSRLHATEFN MLSALNEIYS
YVSKYSEELI GALEQDEQAR RQRLAYKVEH LINAMSIES
//
