ID   G3H6H6_CRIGR            Unreviewed;       688 AA.
AC   G3H6H6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=phospholipase D {ECO:0000256|ARBA:ARBA00012027};
DE            EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027};
GN   ORFNames=I79_005936 {ECO:0000313|EMBL:EGW00010.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00010.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SIMILARITY: Belongs to the phospholipase D family.
CC       {ECO:0000256|ARBA:ARBA00008664}.
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DR   EMBL; JH000174; EGW00010.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3H6H6; -.
DR   STRING; 10029.G3H6H6; -.
DR   InParanoid; G3H6H6; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   InterPro; IPR016555; PLipase_D_euk.
DR   InterPro; IPR015679; PLipase_D_fam.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR   PANTHER; PTHR18896:SF57; PHOSPHOLIPASE D1; 1.
DR   Pfam; PF00614; PLDc; 1.
DR   Pfam; PF00787; PX; 1.
DR   PIRSF; PIRSF009376; Phospholipase_D_euk; 3.
DR   SMART; SM00155; PLDc; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50035; PLD; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        197..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..209
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   DOMAIN          401..428
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   688 AA;  79766 MW;  0D5076B60846A7E7 CRC64;
     MSNLIDNLDT RELHFEGEEV EFDTSPGDPK AQEKYIPFSS IYNTQGFKEP NIQTYLSGCP
     IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFTWQVKRKF KHFQEFHREL LKYKAFIRIP
     IPTKRHTFRR QNVKEEPREM PSLPRSSENT IQEEQFFGRR FFAANTKMLL LPPSPIYPRR
     ILASTSMGLT NSSGNKYLHV FYLGCIYAIP TLPLYFIMNE AFGWLIVKDS FLLYMKPDSG
     AIAFVLLVDK EFRIKVGRKE TETKYGLRID NLSRTLILKC NSYRHARWWG GAIEEFIQKH
     GSDFLKDHRF GSYAAVHENM LAKWLSPEIF LKRPVVEGNR WRLDCILKRK AQQGVRIFIM
     LYKEVELALG INSEYSKRTL MRLHPNIKVM RHPDHVSSSV YLWAHHEKLV IIDQSVAFVG
     GIDLAYGRWD DNEHRLTDVG SVKRVTSGLS MGSLASVDDV DPKLKGVGKP RKFSKFSLYR
     QLHRRHLHNS DSVSSIDSAS NTGSIRSVQT GVGELHGETR FWHGKDYCNF VFKDWVQLDK
     PFADFIDRYS TPRMPWHDIG SVLHGKAARD VARHFIQRWN FTKIMKPKYR SLSYPFLLPK
     SQSTAHELRY QVPGAVPAKV QLLRSAADWS AGIKHHEESI HSAYINVIEN SKHYIYIENQ
     FFISCADDKV VFNKVGDAIA QRILKAHR
//