ID G3H7F0_CRIGR Unreviewed; 2249 AA.
AC G3H7F0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Tudor domain-containing protein 7 {ECO:0000313|EMBL:EGW07920.1};
GN ORFNames=I79_006281 {ECO:0000313|EMBL:EGW07920.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW07920.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH000194; EGW07920.1; -; Genomic_DNA.
DR STRING; 10029.G3H7F0; -.
DR PaxDb; 10029-XP_007609206-1; -.
DR eggNOG; ENOG502QT47; Eukaryota.
DR InParanoid; G3H7F0; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005523; F:tropomyosin binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR CDD; cd09986; LOTUS_1_TDRD7; 1.
DR CDD; cd20428; Tudor_TDRD7_rpt2; 1.
DR CDD; cd20429; Tudor_TDRD7_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.40.50.90; -; 3.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR028089; DUF4455.
DR InterPro; IPR027914; DUF4456.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR004934; TMOD.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047448; Tudor_TDRD7_rpt2.
DR InterPro; IPR047449; Tudor_TDRD7_rpt3.
DR PANTHER; PTHR21444; COILED-COIL DOMAIN-CONTAINING PROTEIN 180; 1.
DR PANTHER; PTHR21444:SF14; COILED-COIL DOMAIN-CONTAINING PROTEIN 180; 1.
DR Pfam; PF14643; DUF4455; 1.
DR Pfam; PF14644; DUF4456; 2.
DR Pfam; PF12872; OST-HTH; 1.
DR Pfam; PF03250; Tropomodulin; 1.
DR Pfam; PF00567; TUDOR; 4.
DR SMART; SM00333; TUDOR; 3.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51644; HTH_OST; 1.
DR PROSITE; PS50304; TUDOR; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 1147..1220
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1353..1433
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 1566..1623
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 244..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2227..2249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..144
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 244..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..388
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2249 AA; 258728 MW; 274738F963E7C215 CRC64;
MDCLSLVRFL YEKIWQECLA HVQNCKKQLL DWKAFSEAEA ESLVNPAFFL VVGEFQSKVE
KKLELLDNSF ETLAKQMEFQ SADLFRYFQE AVKLWEEHQS VLLSQELELE KRIEQHRQKH
NQENQIQEVN LDKLLDQLRQ QSQQETLKSH LEKAKNFLRN MKSRYECFHI LLTKDVMEYP
GLVLKELNCY SFTLSRHFFV REIFEQNLAG EVTFKFRQPE SHEKLFMQKI RKLKKKRKAR
VAIRKAEESI GQETASEKQA EEMEEETVEE TELIMAGEAR SHGDKFPQRG SMDESKEDSS
QEAEELGSMK ETVSEASQEP EHVKSQEENE GVEADKEEEE DQKEEHKEEE EIKEEKEEEE
EGEEEEEEEE MNEEEEEEEE EEDDKMTEDE MEFFQECLFM GLEEGKEESM EEVSNEQKDF
FTTTSGNTYF AFLSVEDEQR VHTRPPSYQV VLFHDPFSTK YIEQVIIPNK LIVKVKKRLR
AGFFEHLEKW FDQCALNAHI IVAAKIDELD SELELRLHLH KPRFQYVERD IHNVRAAELL
LHQERLDSHC AGVIETLKKE RLMFCQFQEE QAVRSRNFRR KIYDMEHIFL NATKSQRLVS
LTNTLHRELL SYVDVIQVSL RSFRQYLEES LGKLRYTNID FVKHCRLFSE GGNFSSEEIE
SLCHRLEKEA TRIEFVESLI MIHMEKMETE YLEQANDVIN KFESKFHNLS SDLIFVEKIQ
RLMTNLQVNI KCQMVAIDDL LAFIRSWKEK LSQRIKYLNC SLDSVSITRE VFTDNTMNDM
DIESDIPASS EVVEEEAKVG LIAPESFSQP TRMGRPMIED PAVDVVKKIL QIPQTKLALA
CDKDRSHTVL KKHRYRGEKS IKKALASSSL TSAGSVTRHA KVIRVDKKYQ VLGEKPPPQS
EDFKGIIMTL LWESNEHLLF VVEDFYRREK RPVTRPEFMY DTFDQCADHI VKKILEYHSQ
VDEYHNSCLL ELRAQVRRFE ELLPQVCWLV TENYKEQHWN KFCASMKEIW EQFEQQQKQL
EKKKEFAKKY SRFFIASLAS FTEKFMLQLD EVVTIDDMQV PRMESQKQKL SLLIRKKLAR
LSLDEESEKS LIDRGSRKWP GIKPNEITIQ TKILTRRTSS ITTSKTTLGH LATIEARDAV
YLVKMLEADL VSKMLRAVLQ SHKNGIALPR LQGEYRSLTG DWIPFKQLGY PTLEAYLRSV
PAVVRIETSR SGEIICYAVA CTETARIAQL VARQRTSKRK TGRQINCQMR VKKTMPFFLE
GKPKATLRQP GFASDYSISK KPNPALLRDK GSTLGVKADV DMPPYPDIPV QRHVSMSASS
RYVGKDYSAA QELMEDEMKE YYSKNPKVTP IQTVHVGQLL AVNAEEDAWL RAQIISTDEN
KIKASSVLSS MSTPGSLSFG FEETSEVCYV DYGFCENVEK SKAYRLNPRF CSLSFQATKC
KLAGLEILND DPDLVKVVES LTCGKIFAVE ILDKSDIPLV VLYDTSGEDD ININATCLKA
ICDKSLEVHL QVDAMYTNVK VTNICSDGTL YCQVPCKGLN KLNDLLHKTE DYFHCKHMTS
EYFISLPFCG KICLFHCKGK WLRVEITNVH SSRALDVQFL DSGNATSVKV SELREIPPRF
LQEMLAIPPQ AIKCCLADLP QSIGMWTPDA VLWLRDSVLN CSDCSIKVTK VDETKGVAYV
YLFTPKNFPD PHRSINRQIT NADLWKHQKD VFLSAVSSAV SSPGSRNGST PAPGSPGEGL
RKSHPEVIRK SVLDHTSSFS LEELPPPVHL SKSGEHMDVY VPVACHPGHF VIQPWQEIHK
LEVLMEEMIL YYSVSEERHI AVERDQVYAA KVENKWYRVL LKGILTNGLV SVYELDYGKH
ELVNIRKVQP LVDVFRKLPF QAVTAQLAGV KCSQWSEEAS MVFRNHVEKK PLVALVQTVI
EHTNPWDRKV VVYLVDTSLP DTDTWIHDFM SQSPVSTEVQ KAKTRPSTMS YRRELEKYRD
LDEDEILGAL TEEELRTLEN ELDELDPDNA LLPAGLRQKD QTTKAPTGPF KREELLDHLE
KQAKEFKDRE DLVPYTGEKR GKIWVPKQKP MDPVLESVTL EPELEEALAN ASDAELCDIA
AILGMHTLMS NQQYYQALGS SSIVNKEGLN SVIKPTQYKP VPDEEPNSTD VEETLERIKN
NDPELEEVNL NNIRNIPIPT LKAYAEALKE NSHVKKFSIV GTRSNDPVAF VCSDPSALLC
SHRALRPGST DEESYGGMAG ASAGSQEGI
//
