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Database: UniProt
Entry: G3H826_CRIGR
LinkDB: G3H826_CRIGR
Original site: G3H826_CRIGR 
ID   G3H826_CRIGR            Unreviewed;       419 AA.
AC   G3H826;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-OCT-2019, entry version 49.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4 {ECO:0000313|EMBL:EGW00861.1};
DE   SubName: Full=KCNJ5 {ECO:0000313|EMBL:RLQ68667.1};
GN   ORFNames=CgPICR_005794 {ECO:0000313|EMBL:RLQ68667.1}, I79_006522
GN   {ECO:0000313|EMBL:EGW00861.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00861.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
RN   [2] {ECO:0000313|EMBL:EGW00861.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RLQ68667.1, ECO:0000313|Proteomes:UP000273346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17A/GY {ECO:0000313|EMBL:RLQ68667.1,
RC   ECO:0000313|Proteomes:UP000273346};
RC   TISSUE=Liver {ECO:0000313|EMBL:RLQ68667.1};
RX   PubMed=29704459; DOI=10.1002/bit.26722;
RA   Rupp O., MacDonald M.L., Li S., Dhiman H., Polson S., Griep S.,
RA   Heffner K., Hernandez I., Brinkrolf K., Jadhav V., Samoudi M., Hao H.,
RA   Kingham B., Goesmann A., Betenbaugh M.J., Lewis N.E., Borth N.,
RA   Lee K.H.;
RT   "A reference genome of the Chinese hamster based on a hybrid assembly
RT   strategy.";
RL   Biotechnol. Bioeng. 115:2087-2100(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; JH000205; EGW00861.1; -; Genomic_DNA.
DR   EMBL; RAZU01000159; RLQ68667.1; -; Genomic_DNA.
DR   RefSeq; XP_003500341.1; XM_003500293.2.
DR   RefSeq; XP_007621156.1; XM_007622966.2.
DR   SMR; G3H826; -.
DR   STRING; 10029.XP_007621156.1; -.
DR   PRIDE; G3H826; -.
DR   Ensembl; ENSCGRT00015011642; ENSCGRP00015009462; ENSCGRG00015007280.
DR   InParanoid; G3H826; -.
DR   OMA; DREWIPC; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   Proteomes; UP000273346; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0098914; P:membrane repolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003277; K_chnl_inward-rec_Kir3.4.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01330; KIR34CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075,
KW   ECO:0000313|Proteomes:UP000273346};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:EGW00861.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     90    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       54    193       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      200    371       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      388    419       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        179    179       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   419 AA;  47798 MW;  41466531F682F2AE CRC64;
     MAGDSRNAMN KDMEIGVTFQ DHKKIPKQAR DYIPIATDRT RLLAEGKKPR QRYMEKSGKC
     NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTIT WLFFGFIWWL IAYVRGDLDH
     VGDQEWIPCV ENLSGFVSAF LFSIETETTI GYGFRVITEK CPEGIILLLV QAILGSIVNA
     FMVGCMFVKI SQPKKRAETL MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK
     SRQTKEGEFI PLNQTDINVG FDTGDDRLFL VSPLIISHEI NEKSPFWEMS RAQLEQEEFE
     VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT FHDTYETNTP
     SCCAKELAEM KRNGRLLQYL PSPPLLGGCA EAGRDAEAEQ DEEDEPNGLS VSQATRGSM
//
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