ID G3H8T9_CRIGR Unreviewed; 689 AA.
AC G3H8T9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Zinc finger protein 334 {ECO:0000313|EMBL:EGV97670.1, ECO:0000313|Ensembl:ENSCGRP00001010808.1, ECO:0000313|RefSeq:XP_027279214.1, ECO:0000313|RefSeq:XP_035302350.1};
GN Name=Znf334 {ECO:0000313|Ensembl:ENSCGRP00001010808.1,
GN ECO:0000313|RefSeq:XP_027279214.1, ECO:0000313|RefSeq:XP_035302350.1};
GN ORFNames=I79_006800 {ECO:0000313|EMBL:EGV97670.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97670.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV97670.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001010808.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027279214.1, ECO:0000313|RefSeq:XP_035302350.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027279214.1,
RC ECO:0000313|RefSeq:XP_035302350.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027279214.1,
RC ECO:0000313|RefSeq:XP_035302350.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000219; EGV97670.1; -; Genomic_DNA.
DR RefSeq; XP_003500569.1; XM_003500521.3.
DR RefSeq; XP_007608532.1; XM_007610342.2.
DR RefSeq; XP_027279214.1; XM_027423413.1.
DR RefSeq; XP_035302350.1; XM_035446459.1.
DR PaxDb; 10029-XP_007608532-1; -.
DR Ensembl; ENSCGRT00001015034.1; ENSCGRP00001010808.1; ENSCGRG00001012608.1.
DR GeneID; 100769274; -.
DR KEGG; cge:100769274; -.
DR CTD; 55713; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163620; -.
DR OMA; ERKRNEC; -.
DR OrthoDB; 4912483at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 6.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF148; ZINC FINGER IMPRINTED 2; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 246..273
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 274..301
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 302..329
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 330..357
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 358..385
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 386..413
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 414..441
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 442..469
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 470..497
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 553..580
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..636
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 637..664
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 665..689
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 75..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 79035 MW; 57F27E2DAE78BB44 CRC64;
MDSSQRLVSF KDLTVDFTRE EWQYLGPAQR LLYRDVTLEN YRNLISLGFR VSKPEVILKL
EQGKEPWIVE ELSSQNHAGK CEDRAEDDDT SEKNKGIQDK HLKQFLAFSN KTMPEKATLF
EKTVALDINT VSSEKTFHKY DPGGNGLKTK SEETVAKQSR ENTKVIAEPD GCEKPLLHTK
PDKSHSVTKR NGCDEVRGVR SQGEALTQDQ SIQSLSQPSE HKGGEPVLQK SAHSAGTGEG
AERKRNECVE CGKTFSKRST LIVHQRIHTG ERPYACSYCR KTFRIKASLT RHQRIHTGER
PYKCQECGKA FIDKSALIVH QRIHGGEKSY ECTECGKTFF RKSALAEHFR SHTGEKPYKC
KECGNAFGKK SYLIVHQRTH RGEKTNECKE CGKTFFCLSA LTAHQRIHSG EKPYECPECE
KTFFCQSALS VHLRSHTGEK PYKCHQCGTS LCTKSALAAH QVIHGGKTSL ECSECGKLFH
LKTTLAIHQR THAGENHGEL SKWGHAPTAN SNGSEQKKVD PKENHYECHE HKPTVHRNSH
HFAHRRTIWE RPYECHECGR TYCRKSALRH HQMTHTGERP YECKDCGKTF YQKVSFIEHQ
RTHTGEKPHK CKQCGKSFRH KSAFTVHKRI HTGEKPYLCN ECGRSYRRLW TLTEHQKIHT
GEKPYECNTC QKTFRHKSNF LLHQNTHKK
//
