ID   G3H9G2_CRIGR            Unreviewed;       671 AA.
AC   G3H9G2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Hedgehog-interacting protein {ECO:0000313|EMBL:EGW00213.1};
GN   ORFNames=I79_007034 {ECO:0000313|EMBL:EGW00213.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00213.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the HHIP family.
CC       {ECO:0000256|ARBA:ARBA00010658}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH000229; EGW00213.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3H9G2; -.
DR   STRING; 10029.G3H9G2; -.
DR   PaxDb; 10029-XP_007611333-1; -.
DR   eggNOG; KOG4295; Eukaryota.
DR   InParanoid; G3H9G2; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR012938; Glc/Sorbosone_DH.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR19328:SF27; HEDGEHOG-INTERACTING PROTEIN; 1.
DR   Pfam; PF03024; Folate_rec; 1.
DR   Pfam; PF07995; GSDH; 1.
DR   SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..671
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003444373"
FT   DOMAIN          35..217
FT                   /note="Folate receptor-like"
FT                   /evidence="ECO:0000259|Pfam:PF03024"
FT   DOMAIN          224..435
FT                   /note="Glucose/Sorbosone dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF07995"
FT   REGION          580..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  75361 MW;  083D84333DD057D5 CRC64;
     MLSFKLLLLA VALGFFEGDA KFGERSEGNG ARRRRCLNGN PPKRLKRRDR RMMSQLELLS
     GGEILCGGFY PRVSCCLQSD SPGLGRLENK IFSSTNNTEC GKLLEEIKCA PCSPHSQSLF
     CSPEREVLDG DLVLPLLCKD YCKEFFYTCR GHIPGLLQTT ADEFCFYYSR KDGGSCFPDF
     PRKQVRGPAS NYLDQMEEYE KVEELSRKHK HNCFCVQEVV SGLRQPVGAV HSGDGSHRLF
     ILEKEGYVKI LTPEGDIFKE PYLDIHKLVQ SGIKGGDERG LLSLAFHPNY KKNGKLYVSY
     TTNQERWAIG PHDHILRVVE YTVSRKNPHQ VDVRTARVFL EVAELHRKHL GGQLLFGPDG
     FLYIILGDGM ITLDDMEEMD GLSDFTGSVL RLDVDTDMCN VPYSIPRSNP HFNSTNQPPE
     VFAHGLHDPG RCAVDRHPTD RNINLTILCS DSNGKNRSSA RILQIMKGKD YESEPSLLEF
     KPFSNGPLVG GFIYRGCQSE RLYGSYVFGD RNGNFLTLQR SPVTKQWQEK PLCLGTSGSC
     RGYFSGHILG FGEDELGEVY ILSSSKSMTQ THNGKLYKII DPKSQESTGG QQKENPYLPD
     DVGLYPSCQP KAATEGRKGN PSDDMDIWIQ VKRVGLSSVL YHELSVCHFW AIKLLVASKV
     LLIHMDSLFQ A
//