ID G3H9I9_CRIGR Unreviewed; 1222 AA.
AC G3H9I9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136};
DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117};
DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820};
DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031};
GN ORFNames=I79_007063 {ECO:0000313|EMBL:EGW11482.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11482.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; JH000231; EGW11482.1; -; Genomic_DNA.
DR AlphaFoldDB; G3H9I9; -.
DR STRING; 10029.G3H9I9; -.
DR eggNOG; KOG1095; Eukaryota.
DR eggNOG; KOG3610; Eukaryota.
DR InParanoid; G3H9I9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625:SF61; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:EGW11482.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1222
FT /note="Hepatocyte growth factor receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003443922"
FT TRANSMEM 852..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..516
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 830..1186
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1031
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1222 AA; 136935 MW; 9B2FBED785647576 CRC64;
MKAPTVLSPG ILVLLLTLLH RSHGECKEAL VKSEMNMNMK YQLPNFTSET PIQNVVLHGH
HIYLGATNYI YVLSDKDLQK VSEYKTGPVL EHPDCFPCQD CSSKANSSGG VWKDNINMAL
LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN TADIQSEVHC MFSPHVDEES GQCPDCVVSA
LGAKVLLSEK DRFINFFVGN TINSTYFPDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPND DILYGVFAQS KPDSAEPMNR
SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
FTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TVPFTPHVNF
LLDSHPVSPE VIVEHPSDQN GYTLVVTGKK ISKIPLNGLG CGHFQSCSQC LSAPSFVQCG
WCHNRCVRSD ECSSGTWTQE ICLPAIYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR
KTKVLLGNES CTLTLSESTT NTVSDSILEC YTPAQTISAE FPVKLKIDLA NRETSGFSYW
EDPIVYEIHP TKSFVSGGST ITGIGKNLNS VSIPKLVIDV HEVGMNYTVA CQHRSNSEII
CCTTPSLQQL GLQLPLKTKA FFLLDGVLSK HFDLTYVHNP VFKPFEKPVV ISMGNENVLE
IKGNDIDPEA VQGEVLKVGN KSCENVHWHS EAVLCTVPND LLKLNSELNI EWKQAVSSTV
LGKVIVQPDQ NFTGLIVGVV SISIILLLLL GLFLWLRKRK HIKDLGSELV RYDARVHTPH
LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG ACRPVQYPLT DLSPILNSGD
SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH FNEVIGRGHF GCVYHGTLLD
NDGKKIHCAV KSLNRLMLLV VEFSDATFIH DRLDEKFTVK VADFGLARDV YDKEYYSVHN
KTGAKLPVKW MALESLQTQK FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG
RRLLQPEYCP DALYEVMLKC WHPKAEMRPS FSELVSRISS IFSTFIGEHY VHVNTTYVNV
KCVAPYPSLL SSQDNIDGEV NT
//
