ID G3H9Y6_CRIGR Unreviewed; 294 AA.
AC G3H9Y6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Cyclin-G1 {ECO:0000256|ARBA:ARBA00019866};
GN Name=Ccng1 {ECO:0000313|Ensembl:ENSCGRP00001020240.1,
GN ECO:0000313|RefSeq:XP_027281032.1};
GN ORFNames=H671_7g18573 {ECO:0000313|EMBL:ERE67586.1}, I79_007219
GN {ECO:0000313|EMBL:EGV97646.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97646.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV97646.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000030759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX PubMed=23929341; DOI=10.1038/nbt.2645;
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puhler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Nat. Biotechnol. 31:694-695(2013).
RN [4] {ECO:0000313|EMBL:ERE67586.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE67586.1};
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puehler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCGRP00001020240.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:XP_027281032.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027281032.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027281032.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in growth regulation. Is associated with G2/M
CC phase arrest in response to DNA damage. May be an intermediate by which
CC p53 mediates its role as an inhibitor of cellular proliferation.
CC {ECO:0000256|ARBA:ARBA00025528}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
CC {ECO:0000256|ARBA:ARBA00010389}.
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DR EMBL; JH000240; EGV97646.1; -; Genomic_DNA.
DR EMBL; KE682190; ERE67586.1; -; Genomic_DNA.
DR RefSeq; XP_003500949.1; XM_003500901.3.
DR RefSeq; XP_027281032.1; XM_027425231.2.
DR STRING; 10029.G3H9Y6; -.
DR PaxDb; 10029-XP_007613919-1; -.
DR Ensembl; ENSCGRT00001024484.1; ENSCGRP00001020240.1; ENSCGRG00001019452.1.
DR GeneID; 100771963; -.
DR KEGG; cge:100771963; -.
DR CTD; 900; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000154726; -.
DR OMA; CFEAQEE; -.
DR OrthoDB; 3032827at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000030759; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd20583; CYCLIN_CCNG1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177:SF59; CYCLIN-G1; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 56..142
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 294 AA; 34035 MW; 5C34D4012D4F3004 CRC64;
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL RDFEVKDLLS
LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC FYLAVKSIEE ERNVPLATDL
IRISQYRFTV SDLMRMEKIV LEKVCWKVKA TTAFQFLQLY YSLIQDSLPF ERRNDLNFER
LEAQLKACHC RIIFSKAKPS VLALSIIALE IQALKYVELM EGIECIQKHS KINSRDLTFW
QELVSKCLTE YSSNKCSKPN VQKLKWIVSG RTARQLKHSY YRITHLPTIP ETVS
//
