ID G3HBK9_CRIGR Unreviewed; 665 AA.
AC G3HBK9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Transcriptional repressor CTCFL {ECO:0000313|EMBL:EGW11010.1, ECO:0000313|RefSeq:XP_027279060.1};
GN Name=Ctcfl {ECO:0000313|RefSeq:XP_027279060.1};
GN ORFNames=I79_007843 {ECO:0000313|EMBL:EGW11010.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW11010.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW11010.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_027279060.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027279060.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027279060.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH000271; EGW11010.1; -; Genomic_DNA.
DR RefSeq; XP_003501481.1; XM_003501433.1.
DR RefSeq; XP_027279060.1; XM_027423259.2.
DR STRING; 10029.G3HBK9; -.
DR PaxDb; 10029-XP_007633462-1; -.
DR GeneID; 100759040; -.
DR KEGG; cge:100759040; -.
DR CTD; 140690; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; G3HBK9; -.
DR OrthoDB; 5398475at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP001108280; Chromosome 6.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24408:SF58; LINKING IMMUNITY AND METABOLISM-RELATED; 1.
DR PANTHER; PTHR24408; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 268..295
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 296..323
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 324..352
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 353..380
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 381..408
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 409..437
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 439..463
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..524
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..548
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 557..583
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 75389 MW; C4E09100C534ACD5 CRC64;
MAAAEVPVPS EHFTQIKEQK LKPGDLEEEK EEGGVQRMEA QEGAVEAEAV PCQLLDAAAG
LQKDQPELPL WVPAVESDRR VLTLQTVHLT SQDVQLQGLG WLSVPHSEFP VTIPQEESFL
PLPSVLWLEQ ESQPSLQHCM TVSIPEELYQ PEDVGLTHFQ LLQQSVPAAE EDPELTPNSG
GSAAQTKFED EEQDQLLPEA GEPDTKEEEK FLFVEMTPND EKRDEIVLTI SHLSLEEQQD
QSAPKQTSAP NAETTKPPER GKGKTRTFQC EFCPFTSSKF STFTRHVKIH NDERPHLCHL
CLKGFRTVTL LRNHVNTHTG TRPYKCGDCG MAFVTSGELV RHRRYKHTHE KPFKCSICKY
ASVEASKLKR HIRSHTGERP FQCCQCTYAS KDTYKLKRHM RTHSGEKPYE CPTCHARFTQ
SGTMKIHVAQ KHGENVPKHE CPHCATVIAR KSDLRVHLRN LHSHSPVEIK CRYCPAGFHE
RYALIQHQRS HKNEKKFKCK QCDYACKQER CLKAHVRTHT GEKPFSCLDC SKHFRQKQLL
TVHLRKYHDP SFVPDVHLCL KCDKGFSRWS NLQRHRKKCD PEHEKLATSR KASQVMQKQT
VEETPGWDND VATQESHTSK EAQCPGELAL CHHGGGGGGG GESAAGSENM DEGLTCEMLF
NMMDK
//
