ID G3HBX8_CRIGR Unreviewed; 837 AA.
AC G3HBX8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Telomere length regulation protein TEL2 homolog {ECO:0000256|ARBA:ARBA00018231};
GN Name=Telo2 {ECO:0000313|Ensembl:ENSCGRP00001027847.1,
GN ECO:0000313|RefSeq:XP_027280825.1, ECO:0000313|RefSeq:XP_027280826.1,
GN ECO:0000313|RefSeq:XP_027280827.1, ECO:0000313|RefSeq:XP_027280828.1,
GN ECO:0000313|RefSeq:XP_027280829.1};
GN ORFNames=I79_007930 {ECO:0000313|EMBL:EGW04415.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04415.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW04415.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001027847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027280825.1, ECO:0000313|RefSeq:XP_027280826.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027280825.1,
RC ECO:0000313|RefSeq:XP_027280826.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027280825.1,
RC ECO:0000313|RefSeq:XP_027280826.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TEL2 family.
CC {ECO:0000256|ARBA:ARBA00006133}.
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DR EMBL; JH000273; EGW04415.1; -; Genomic_DNA.
DR RefSeq; XP_003501530.1; XM_003501482.3.
DR RefSeq; XP_007640362.1; XM_007642172.2.
DR RefSeq; XP_007640363.1; XM_007642173.2.
DR RefSeq; XP_007640364.1; XM_007642174.2.
DR RefSeq; XP_007640365.1; XM_007642175.2.
DR RefSeq; XP_027280825.1; XM_027425024.2.
DR RefSeq; XP_027280826.1; XM_027425025.2.
DR RefSeq; XP_027280827.1; XM_027425026.2.
DR RefSeq; XP_027280828.1; XM_027425027.2.
DR RefSeq; XP_027280829.1; XM_027425028.2.
DR STRING; 10029.G3HBX8; -.
DR PaxDb; 10029-XP_007640361-1; -.
DR Ensembl; ENSCGRT00001032095.1; ENSCGRP00001027847.1; ENSCGRG00001024725.1.
DR GeneID; 100774669; -.
DR CTD; 9894; -.
DR eggNOG; KOG4346; Eukaryota.
DR GeneTree; ENSGT00390000006698; -.
DR OMA; YDKKRHG; -.
DR OrthoDB; 8746at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0110078; C:TTT Hsp90 cochaperone complex; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR Gene3D; 1.25.40.720; Telomere length regulation protein 2, C-terminal domain; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038528; TEL2_C_sf.
DR InterPro; IPR019337; Telomere_length_regulation_dom.
DR PANTHER; PTHR15830; TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER; 1.
DR PANTHER; PTHR15830:SF10; TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG; 1.
DR Pfam; PF10193; Telomere_reg-2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 512..620
FT /note="Telomere length regulation protein conserved"
FT /evidence="ECO:0000259|Pfam:PF10193"
FT REGION 442..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 92905 MW; E37C27F15C565FBF CRC64;
MDPALSAVRL TVQEAIHTLS SSEDVGHILS TLGTLKRYLG GTEDPALPEK EEFTTIHFSA
ILRCLVSKLS PGWLELSPDG QLEQLWESFF LDGPPDQAFL VLMEAIESTA GPSFRLMKMA
RLLEIFLSKG RVAALMEEQC RPQTKPSFPL FQETLLSKVV GLPDRLGNSL QQDNLTQFLP
QNYFPLLGQE VVEVLKAVVN FLQGGLDCSV SFVSRVLGKV CIQGRKKEIL GVLVPQLTVL
TQDSCLWQRV CWRLVEQVPD RAVEAVLTGL VEAAPRPEVL SRLLGNLVVK NKKAQFVMTR
KLLFLQYQHT TPMLQSLLGY LAVDSQRRPL LIQVLKELLE TWGNSSAVRH APLEQQCYIS
KAILVCLAHL GEPELQDIQD ELLASMMAGV KCRLDSSLPP VRRLGMIVAE VISSRIHPEG
PPLKFQYEDD EMSREMLALA TPGPAGACSS ETGGPSLASV VTETPVETPE KTVDSDVPSV
QPQGSDSELD SDDEFIPYDM SGDKELKSSK EPRYIRDCLE ALTTSEDMER WEAALNVLEG
LVYRSPEATR EVSVELAKVL LHLEEKTCMA EFEQLRQRAL VAVTVTDPEQ VAKYLTTQFY
GLNYSLRQRM DILDVLVLAA QALSRPRSLQ RLSQHGPPGS GTLCAPALAS SQPGNAATPD
WQVVVEERIK SKTRRFSKGC PRRELTGGPN EFNSVAGYFF FPLLQHFDRP LVTFDLLGDD
QLVLGRLAHT LASLMYLAVN TTVAVPMGKA LLEFVWALRF HVDTYVRRGL LSAVSSVLLS
VPTERLLGDL PDELLEARSW LADVAEKDVD EDCRELAMRA LLLLERLRDK LLSISSP
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