ID G3HC39_CRIGR Unreviewed; 375 AA.
AC G3HC39;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Farnesyl pyrophosphate synthase {ECO:0000256|ARBA:ARBA00034546};
DE AltName: Full=(2E,6E)-farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032873};
DE AltName: Full=Dimethylallyltranstransferase {ECO:0000256|ARBA:ARBA00032448};
DE AltName: Full=Farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032424};
DE AltName: Full=Geranyltranstransferase {ECO:0000256|ARBA:ARBA00032380};
GN ORFNames=I79_007989 {ECO:0000313|EMBL:EGV98075.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98075.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-
CC farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769,
CC ChEBI:CHEBI:175763; EC=2.5.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001744};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-
CC geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057,
CC ChEBI:CHEBI:128769; EC=2.5.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000969};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis;
CC farnesyl diphosphate from geranyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00005035}.
CC -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis;
CC geranyl diphosphate from dimethylallyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004932}.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; JH000275; EGV98075.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HC39; -.
DR STRING; 10029.G3HC39; -.
DR PaxDb; 10029-XP_007612588-1; -.
DR eggNOG; KOG0711; Eukaryota.
DR InParanoid; G3HC39; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR InterPro; IPR039702; FPS1-like.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR11525:SF0; FARNESYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR11525; FARNESYL-PYROPHOSPHATE SYNTHETASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..375
FT /note="Farnesyl pyrophosphate synthase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003444429"
SQ SEQUENCE 375 AA; 43211 MW; 4D12C46316BAC3C2 CRC64;
MPLSRLLRSA GVFLLPAPCW APRERWLGSL QRPSLAYGCT VLGAWHSARW WCQVWTEQPR
VFCSSLRMNG NQKLDACNQE RQDFIQHFSQ IVKVLTEDGL GHPETGDAIT RLKEVLEYNA
VGGKYNRGLT VLQAYRELVE PRKQDAESLQ RALTVGWCVE LLQAFFLVSD DIMDSSLTRR
GQICWYQKPG IGLDAINDAM LLEACIYRLL KFYCREQPYY LNLLELFLQS SYQTEIGQTL
DLITAPQGHV DLDRYTEKRY KSIVKYKTAF YSFYLPVAAA MYMAGIDGEK EHANAKKILL
EMGEFFQIQD NYGQKDPDKV AQVKALYEAL DLPAVFLKYE EDSYSRLKSL IEQYSAPLPQ
AIFLELAKKI YKRKK
//
