ID   G3HE63_CRIGR            Unreviewed;      1396 AA.
AC   G3HE63;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Adenylate cyclase type 10 {ECO:0000313|EMBL:EGW08788.1};
GN   ORFNames=I79_008837 {ECO:0000313|EMBL:EGW08788.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW08788.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH000310; EGW08788.1; -; Genomic_DNA.
DR   STRING; 10029.G3HE63; -.
DR   eggNOG; ENOG502QPPT; Eukaryota.
DR   InParanoid; G3HE63; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR16305:SF32; ADENYLATE CYCLASE TYPE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          1..126
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          288..365
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1396 AA;  159270 MW;  AC24FC8A088D724E CRC64;
     MTEKFSTAMY MDRGAEQLVE ILNYYISAIV EKVLIFGGDI LKFAGDALLA LWKVERKQLK
     NIITVVIKCS LEIHGLFEAK EAEEGLDIRV KIGLAAGHIT MLVFGDETRN YFLVIGQAVD
     DVRLAQNMAH MNDVILSPNC WQLCDRSMIE IERIPDQRAV KVSFLKPPPT FNFDEFFAKC
     MAFMDYYPSG DHKNFLRLAC MLESDPELEL SLQKYVMEII LKQIDDKQLR GYLSELRPVT
     IVFVNLMFKE QDKAEVIGSA IQAACVHITS VLKVFRGQIN KVFMFDKGCS FLCVFGFPGE
     KAPDEITHAL ESAVDIFDFC SQVHKIRTVS IGVASGIVFC GIVGHTVRHE YTVIGQKVNI
     AARMMMYYPG IVTCDSVTYD GSNLPAYFFK ELPKKVMKGV ADSGPVYQCL GLNEKVMFGM
     AYLICNRYEG YPLLGNTSVP GSASFIPPPP PTPFPDPPCA AASAIMKNRN TTYIAVGRMQ
     PQEIRDKVCV DLSVSSIPTE LDSAIAIALT KISFHQNFYT IQILMANVLG LDTCKHYKER
     QTSLQSKVKM LLDDKFHCLL NDIFHVQFPV SREMSRMSAL RKQMQLEALF MKILEQTVKE
     EKIIFIIDEA QFVDETSWAF IEKLIRCMPI FIIMSLPPFP DIPCAAASAI MKNRNTTYIA
     VGRMQPQEIR DKVCVDLSVS SIPTELDSYL VEGSCGIPFY CEELLKNLDH HRVLLFQQAE
     SEEKTNVTWN NLFKNSVRPT EDINIYTSIS EGRKEVCYLA SGVRLKNLSP PASLKEISLV
     QLDSMSLSHQ MLVRCAAIIG LTFTTELLFE ILPCWNMKTM IKALATLVES NVFDCFRSRK
     DLQLALKQNV ATLEVHYRSL SLNPNEGLGR CEEELREMEG EVIECRILRF CRPIMQKTAY
     ELWLKDQKKV LHLKCARFLE ESAHRCNHCR NRDFIPYHHF IVDIRLNTLD MHTVKKMAKS
     QGFKSKIYFT SNQSQLVLGS PGESNLYGLG QDLKAFNTPG VWDTSHVIGS WGREELAMHK
     EWQSPSHCDF HTELWQMSSC SEIKMSHSKG WSPEDVIPLE SCQCEELLQI VLLPLAQHFV
     ALEENNKALY YFLEVASAYL ILGDNYKIIK AFLDYSLYHH LAGYQGLWYK YEILVVEQLL
     NLPMKAEAIE TIAYVADTLG HIKFLMGHLD LAIELGFIYR TFEECLEFIH HNEDNRILRF
     QSGLLLGLYS SIAVWYARLQ EWDNFDKYSN RAKSLVTRRT PTVLYYEGIS RYMEGQALYL
     QKQIEEQVEN AQDSGVELLK ALENLVGQNT TGPVFYPRLY HLMAYVCILM GDGHSCDFFL
     NTALELSETQ GNLLEKCWLS MSKEWWYSAS ELIGDHWLQT VLSLPSWDKI VSGSVPLQDV
     QKNKFLMRVN ILDNPF
//