ID G3HE68_CRIGR Unreviewed; 123 AA.
AC G3HE68;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=T-cell surface glycoprotein CD3 zeta chain {ECO:0000256|ARBA:ARBA00020448};
DE AltName: Full=T-cell receptor T3 zeta chain {ECO:0000256|ARBA:ARBA00030941};
DE Flags: Fragment;
GN ORFNames=I79_008844 {ECO:0000313|EMBL:EGW08793.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW08793.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family.
CC {ECO:0000256|ARBA:ARBA00007280}.
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DR EMBL; JH000310; EGW08793.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HE68; -.
DR STRING; 10029.G3HE68; -.
DR InParanoid; G3HE68; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:UniProt.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR InterPro; IPR024128; T-cell_CD3_zeta.
DR PANTHER; PTHR10035; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR PANTHER; PTHR10035:SF2; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR Pfam; PF02189; ITAM; 1.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EGW08793.1"
SQ SEQUENCE 123 AA; 13621 MW; 62412C111C1EA53B CRC64;
GTEAQSFGLL DPKLCYLLDG ILFIYGVIVT ALYLRAKFSG SVDATAYQQG SNQLYNELSL
GRREEYDVLD KKWARDPEVG GKQALQKDKM AEAYSEIGMK GEGLSTATKD TYDALNMQTL
PPR
//
