ID G3HEV8_CRIGR Unreviewed; 460 AA.
AC G3HEV8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Solute carrier family 30 member 6 {ECO:0000313|Ensembl:ENSCGRP00001016242.1};
DE SubName: Full=Zinc transporter 6 {ECO:0000313|EMBL:EGW02706.1, ECO:0000313|RefSeq:XP_027281893.1};
GN Name=Slc30a6 {ECO:0000313|Ensembl:ENSCGRP00001016242.1,
GN ECO:0000313|RefSeq:XP_027281893.1};
GN ORFNames=I79_009105 {ECO:0000313|EMBL:EGW02706.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW02706.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW02706.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001016242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027281893.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027281893.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027281893.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer with SLC30A5; form a functional zinc ion
CC transmembrane transporter. {ECO:0000256|ARBA:ARBA00038600}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|ARBA:ARBA00008873}.
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DR EMBL; JH000321; EGW02706.1; -; Genomic_DNA.
DR RefSeq; XP_003502536.1; XM_003502488.3.
DR RefSeq; XP_007633043.1; XM_007634853.2.
DR RefSeq; XP_027281893.1; XM_027426092.2.
DR STRING; 10029.G3HEV8; -.
DR PaxDb; 10029-XP_007633043-1; -.
DR Ensembl; ENSCGRT00001020486.1; ENSCGRP00001016242.1; ENSCGRG00001016614.1.
DR GeneID; 100763102; -.
DR KEGG; cge:100763102; -.
DR CTD; 55676; -.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000159934; -.
DR OMA; FNCLHIS; -.
DR OrthoDB; 11451at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0071579; P:regulation of zinc ion transport; IEA:Ensembl.
DR GO; GO:1904257; P:zinc ion import into Golgi lumen; IEA:Ensembl.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR46531; ZINC TRANSPORTER 6; 1.
DR PANTHER; PTHR46531:SF1; ZINC TRANSPORTER 6; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00022906};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022906};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 435..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50818 MW; D3FB049A777C4076 CRC64;
MGTIHLFRKP QRSFFGKLLQ EFRLVAADRR SWKILLFGAV NVLCTGFLLM WCSSTNSIAL
TAYTYLTIFD LFSLITCLIS YWVMMRKPSP AYSFGFERLE VLAVFASTVL AQLGALFILK
ESAERFLDQP EIHTGRLLVG TFVALSFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS
RSVCGIIPGL SSIFLPRMNP FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF
GTMYPMSVYS GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH
VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPA LLSGPVASNA LNFSDHHIIP
MPLLKNVDDR IPVTSTPAKP SSPPPEFSFN TPGKNVSPVI LLNTQTRPYG LGLSRGHTPY
SSVLGQGLAV PGVGAGQGLR PTFPHVPSRY GNNRTGQPRP
//
