ID G3HHL9_CRIGR Unreviewed; 917 AA.
AC G3HHL9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zinc finger protein 39 {ECO:0000313|EMBL:EGV98925.1};
GN ORFNames=I79_010123 {ECO:0000313|EMBL:EGV98925.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98925.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JH000381; EGV98925.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HHL9; -.
DR STRING; 10029.G3HHL9; -.
DR PaxDb; 10029-XP_007642122-1; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; G3HHL9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24399:SF54; GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED; 1.
DR PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT TRANSMEM 20..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..179
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DOMAIN 198..270
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 407..434
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 541..568
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 592..619
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 620..647
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 648..675
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 676..703
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 713..907
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 718..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 104907 MW; 50493B9E71717370 CRC64;
MSNHTRVTHF ILRGFSDAPL LRLVVIPFFL LVYTFGLLGN ISIITAVMRD SRLHSPMYFF
LKNLSFLDMC YTSATIPKAM VISFTGSGVI SYIECVAQLY IFITLSATEC FLLTAMAYDR
FLAILRPLLY GTIMSQKCRA EMVASAWASG AIYSAFHTFN TFSLPYCGPN IVEHFFCDIP
PVMRLSCTDY HLNEEGLVTF EDVCVDFTWD EWQDLDDAQR KLYRDVMLET YSSLLSLNMQ
HVNDPNEISQ DNRQIHGCNL VIAKSSTSAE ERAKAGKTLT SSNCVLRLAV KSNMSSGMRP
RALNMWDNAL LPSEPSEMQA VEELDLPNVT RMSPRFPEPL SLYHSTKCEE QHFQYCGHGK
AFHTKTMWLQ NAFPIRDPSS KLKNYKKGLE KLAFPTQGGI EVQEQTFECK VCGKLFYKNC
HLTQHLKTHK EKKCYKGNDC EPIFSIQSNV PKHQHLNVGE ESYTCNEDEK YTCQKPEKSV
QQRIMGDGKN VYRKTICSKL NHSVQQSPHK NEKSHECSIS GKTIIKSDLQ LQTPHRYENA
YECNTCGKTF NHTPHVYSHS RANTAEKPYE CRDCQQSKLI VNQQTHTQEK RYVCNVCGKG
FYKRAHLNAH QRTHTGEKPY DCKECGKTFR LKSFLVVHQR IHTGEKPFVC NTCGKSFKQR
TSLYTHIRIH TGEKPYECKE CRKSFILKSY LTVHQRTHSD QCDAKPELIL KLEQGAGPWK
EEDAPNQRLP DSLSLDPETS SPKLVVSENQ KSVKRLLFDQ DLSPSSKRFD QDPCILAQEQ
FDAGRHYWEV EVGDRRAWIL GVCLESLGRE GRIPKSPQHG LWALEFYKKK LQALSYPRTH
LSLPQPICRV GIFLDFEAGK ISFHNAVNGF LIYVFSGLSF SGPLQPFFCL WTHDPRPLTI
CSVVRETEEV TDSSEGP
//
