ID G3HHR9_CRIGR Unreviewed; 944 AA.
AC G3HHR9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Integrin alpha-V {ECO:0000313|EMBL:EGV92020.1};
GN ORFNames=I79_010178 {ECO:0000313|EMBL:EGV92020.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV92020.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JH000385; EGV92020.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HHR9; -.
DR STRING; 10029.G3HHR9; -.
DR PaxDb; 10029-XP_007626259-1; -.
DR eggNOG; KOG3637; Eukaryota.
DR InParanoid; G3HHR9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0034674; C:integrin alpha5-beta1 complex; IDA:CAFA.
DR GO; GO:0001968; F:fibronectin binding; IDA:CAFA.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IDA:CAFA.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF4; INTEGRIN ALPHA-V; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 890..912
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 46..107
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 138..192
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 193..258
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 259..316
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 320..383
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 368..526
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 527..665
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 673..879
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 923..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 104735 MW; 09EDB4066C25008D CRC64;
MFLLVGAPKA NTTQPGIVEG GQVLKCDCSS SRRCQPIEFD STGNRDYAKD DPLEFKSHQW
FGASVRSKQD KILACAPLYH WRTELKQERE PVGTCFLQDG TKTVEYAPCR SSQLISDQVA
EIISKYDPNV YSIKYNNQLA TRAAQAIFDD SYLGYSVAVG DFNGDGIEDF VSGVPRAART
LGMVYIYDGK NMSSLHNFTG EQMAAYFGFS VAATDINGDD YADVFIGAPL FMDRGSDGKL
QEVGQVSVSL QRALGDFQTT KLNGFEVFAR FGSAIAPLGD LDQDGFNDIA IAAPYGGEDQ
KGLVYIFNGR STGLNSVPSQ ILEGQWAAQS MPPSFGYSMK GATDVDRNGY PDLVVGAFGV
DRAILYRARP VVTVNAGLEV YPSILNQDNK ICPLPGTSLK VSCFNVRFCL KADGKGTLPK
RLNFQVELLL DKLKQKGAIR RALFLHNRSP GHSKNMTVFR GGQMQCEELV AYLRDESEFR
DKLTPITIFM EYRLDHRTAA DVTGLQPILN QFTPANVSRQ AHILLDCGED NVCKPKLEVS
VDSDQKKIYI GDDNPLTLTV KAQNQGEGAY EAELIVSIPP QADFIGVVRN NEALARLSCA
FKTENQTRQV VCDLGNPMKA GTQLLAGLRF SVHQQSEMDT SVKFDLKIQS SNSFDNVSPV
VSYKVDLAVL AAVEIRGVSS PDHIFLPIPN WEYKENPETE EDVGPVVQHI YELRNNGPSS
FSKAILNLQW PYKYNNNTLL YILHYDIDGP MNCTADTEIN PLRIKIPEKN DTSTGQGDRH
HLITKRDLTL SEGDVHTLGC GVAKCLQIIC QVGRLDRGKS AILYVKSLLW TETFMNKENQ
NHSYSLKSSA SFNIIEFPYK NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIIMAVLAG
LLLLAVLVFV MYRMGFFKRV RPPQEEQERE QLQPHENGEG NSET
//
